Serene Lemon Balm honey™

(1 customer review)

£10.00

Serene Lemon Balm honey™ is a testament to the art of harmonious combinations, where every ingredient plays its part to create a delightful blend that calms and comforts. Whether you’re winding down after a long day or seeking a peaceful reprieve, this honey offers a serene escape. Allow the gentle allure of Relaxing Honey to transport you to a world of tranquillity and warmth, where nature’s finest ingredients unite in perfect harmony, inviting you to unwind and savour life’s quieter moments.

Description

Unwind and indulge in the tranquil bliss of our relaxing honey, a divine infusion of acacia honey blended with the soothing nuances of lemon balm and hops. This exceptional honey is a delightful journey through flavours that are crafted to help you discover relaxation in its purest form.

At the heart of the Senere Lemon Balm honey™ lies the gentle sweetness of acacia honey, sourced from the delicate blooms of the Black Locust tree. Its exquisite golden hue sets the stage for a symphony of taste and serenity.

Lemon balm is a fragrant herb with bright, citrusy notes, that imparts a refreshing and uplifting layer to the blend. The zesty twist it brings is like a breath of fresh air for your senses. The hops, known for their role in brewing, introduce a unique earthy richness to this elixir. Their subtle bitterness beautifully complements the honey’s sweetness, creating a harmonious balance that’s both inviting and comforting.

We are unable to provide you with all the medicinal benefits on this website, but are happy to discuss your needs in a free, private consultation.

Additional information

Weight 410 g

Taste Profile

Light, mild and citrussy flavour.

Benefits

This honey has health benefits, both internally and externally, but, legally we are prohibited from advertising these benefits. Please contact us for a free, personal consultation.

Use

For general anxiety and relaxation: 1-2 teaspoons, 1-3 times daily.

As a sleep aid: 1-2 teaspoons taken just before sleep.

Ingredients

Acacia honey infused with: Lemon Balm | Hops

Certified Origins

Hungarian flag denoting that one or more ingredients are ethically sourced from Hungary.Polish flag denoting that one or more ingredients was ethically sourced from Poland.Serbian flag denoting that one or more ingredients was ethically sourced from Serbia.

Macerated and bottled in Shropshire, England.

Clinical References

Clinical evidence of the ingredients found in this product. These are public domain references and do not relate directly to our product.

  • Abd Ghafar N, Ker-Woon C, Hui CK, Mohd Yusof YA, Wan Ngah WZ. Acacia honey accelerates in vitro corneal ulcer wound healing model. BMC Complement Altern Med. 2016 Jul 29;16:259. doi: 10.1186/s12906-016-1248-0. PMID: 27473120; PMCID: PMC4966736.
  • Abuhamdah, S., Huang, L., Elliott, M. S., Howes, M. J., Ballard, C., Holmes, C., Burns, A., Perry, E. K., Francis, P. T., Lees, G., and Chazot, P. L. Pharmacological profile of an essential oil derived from Melissa officinalis with anti-agitation properties: focus on ligand-gated channels. J Pharm Pharmacol. 2008;60(3):377-384.
  • Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6.
  • Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® – Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  • Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11.
  • Alikiaie B, Shahmoradi E, Yekdaneh A, Mousavi S. Addition of Valerian and Lemon Balm Extract to Quetiapine Reduces Agitation in Critically Ill Patients with Delirium: A Pilot Randomized Clinical Trial. Indian J Crit Care Med 2021;25(7):785-790.
  • Aliyu M, Odunola OA, Farooq AD, Rasheed H, Mesaik AM, Choudhary MI, Channa IS, Khan SA, Erukainure OL. Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line. Nutr Cancer. 2013;65(2):296-304. doi: 10.1080/01635581.2013.756920. PMID: 23441617.
  • Allahverdiyev, A., Duran, N., Ozguven, M., and Koltas, S. Antiviral activity of the volatile oils of Melissa officinalis L. against Herpes simplex virus type-2. Phytomedicine. 2004;11(7-8):657-661.
  • Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207.
  • Araujo, C., Sousa, M. J., Ferreira, M. F., and Leao, C. Activity of essential oils from Mediterranean Lamiaceae species against food spoilage yeasts. J Food Prot. 2003;66(4):625-632.
  • Assessment report on Humulus lupulus L., flos. European Medicines Agency, 2014. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-humulus-lupulus-l-flos_en.pdf. Accessed September 29, 2021.
  • Auf’mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34.
  • Awad, R., Levac, D., Cybulska, P., Merali, Z., Trudeau, V. L., and Arnason, J. T. Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Can.J Physiol Pharmacol. 2007;85(9):933-942.
  • Awad, R., Muhammad, A., Durst, T., Trudeau, V. L., and Arnason, J. T. Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. Phytother.Res. 2009;23(8):1075-1081.
  • Babpour, E., Angaji, S. A., and Angaji, S. M. Antimicrobial effects of four medicinal plants on dental plaque. Journal of Medicinal Plants Research 2009;3(3):132-137.
  • Ballard CG, O’Brien JT, Reichelt K, Perry EK. Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa. J Clin Psychiatry 2002 Jul;63:553-8.
  • Bisler H, Pfeifer R, Kluken N, Pauschinger P. [Effects of horse-chestnut seed on transcapillary filtration in chronic venous insufficiency]. Dtsch Med Wochenschr 1986;111:1321-9.
  • Bolca, S., Li, J., Nikolic, D., Roche, N., Blondeel, P., Possemiers, S., De, Keukeleire D., Bracke, M., Heyerick, A., van Breemen, R. B., and Depypere, H. Disposition of hop prenylflavonoids in human breast tissue. Mol Nutr Food Res 2010;54 Suppl 2:S284-S294.
  • Borho, B. Biologische Therapie von funktionellen Magenerkrankungen. 1991;6:501-509.
  • Bucekova M, Jardekova L, Juricova V, Bugarova V, Di Marco G, Gismondi A, Leonardi D, Farkasovska J, Godocikova J, Laho M, Klaudiny J, Majtan V, Canini A, Majtan J. Antibacterial Activity of Different Blossom Honeys: New Findings. Molecules. 2019 Apr 21;24(8):1573. doi: 10.3390/molecules24081573. PMID: 31010070; PMCID: PMC6514785.
  • Buchner KH, Hellings H, Huber M, and et al. [Double blind study as evidence of the therapeutic effect of Melissengeist on psycho-vegetative syndromes]. Medizinische Klinik 1974;69(23):1032-1036.
  • Budzynska, A., Wieckowska-Szakiel, M., Sadowska, B., Kalemba, D., and Rozalska, B. Antibiofilm activity of selected plant essential oils and their major components. Pol.J.Microbiol. 2011;60(1):35-41.
  • Burns A, Byrne J, Ballard C, Holmes C. Sensory stimulation in dementia. BMJ 2002;325:1312-3.
  • Burns A, Perry E, Holmes C, et al. A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer’s disease. Dement Geriatr Cogn Disord. 2011;31:158-64.
  • Caballero, I., Agut, M., Armentia, A., and Blanco, C. A. Importance of tetrahydroiso alpha-acids to the microbiological stability of beer. J AOAC Int 2009;92(4):1160-1164.
  • Cases J, Ibarra A, Feuillère N, Roller M, Sukkar SG. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Med J Nutrition Metab. 2011;4(3):211-218.
  • Cases J. Leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Mediterr J Nutr Metab. 2010;4(3):211-218.
  • Cerny A, Shmid K. Tolerability and efficacy of valerian/lemon balm in healthy volunteers (a double blind, placebo-controlled, multicentre study). Fitoterapia 1999;70:221-8.
  • Cerny AS and Schmid K. Tolerability and efficacy of valerian/lemon balm in healthy volunteers; a double-blind placebo-controlled, multicentre study. Fitoterapia 1999;70(3):221-228.
  • Chadwick LR, Pauli GF, Farnsworth NR. The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties. Phytomedicine 2006;13(1-2):119-31.
  • Chadwick, L. R., Nikolic, D., Burdette, J. E., Overk, C. R., Bolton, J. L., van Breemen, R. B., Frohlich, R., Fong, H. H., Farnsworth, N. R., and Pauli, G. F. Estrogens and congeners from spent hops (Humulus lupulus). J Nat.Prod. 2004;67(12):2024-2032.
  • Chakurski I, Matev M, Koichev A, et al. [Treatment of chronic colitis with an herbal combination of Taraxacum officinale, Hipericum perforatum, Melissa officinaliss, Calendula officinalis and Foeniculum vulgare]. Vutr Boles. 1981;20:51-4.
  • Chiummariello, S., De, Gado F., Monarca, C., Ruggiero, M., Carlesimo, B., Scuderi, N., and Alfano, C. [Multicentric study on a topical compound with lymph-draining action in the treatment of the phlebostatic ulcer of the inferior limbs]. G.Chir 2009;30(11-12):497-501.
  • Choi, Y., Jermihov, K., Nam, S. J., Sturdy, M., Maloney, K., Qiu, X., Chadwick, L. R., Main, M., Chen, S. N., Mesecar, A. D., Farnsworth, N. R., Pauli, G. F., Fenical, W., Pezzuto, J. M., and van Breemen, R. B. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Anal.Chem 2-1-2011;83(3):1048-1052.
  • Chung MJ, Cho SY, Bhuiyan MJ, et al. Anti-diabetic effects of lemon balm ( Melissa officinalis) essential oil on glucose- and lipid-regulating enzymes in type 2 diabetic mice. Br.J.Nutr. 2010;104:180-188.
  • Chung, W. G., Miranda, C. L., Stevens, J. F., and Maier, C. S. Hop proanthocyanidins induce apoptosis, protein carbonylation, and cytoskeleton disorganization in human colorectal adenocarcinoma cells via reactive oxygen species. Food Chem Toxicol. 2009;47(4):827-836.
  • Cohen RA, Kucera LS, and Herrmann EC. Antiviral activity of Melissa officinalis (lemon balm) extract (29600). Proceedings of the Society for Experimental Biology and Medicine 1964;117:431-434.
  • Colgate EC, Miranda CL, Stevens JF, et al. Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Cancer Lett 2007;246:201-9.
  • Cornu, C., Remontet, L., Noel-Baron, F., Nicolas, A., Feugier-Favier, N., Roy, P., Claustrat, B., Saadatian-Elahi, M., and Kassai, B. A dietary supplement to improve the quality of sleep: a randomized placebo controlled trial. BMC.Complement Altern Med 2010;10:29.
  • Czipa N, Phillips CJC, Kovács B. Composition of acacia honeys following processing, storage and adulteration. J Food Sci Technol. 2019 Mar;56(3):1245-1255. doi: 10.1007/s13197-019-03587-y. Epub 2019 Jan 28. PMID: 30956304; PMCID: PMC6423237.
  • Dall’Acqua S, Perissutti B, Grabnar I, Farra R, Comar M, Agostinis C, et al. Pharmacokinetics and immunomodulatory effect of lipophilic Echinacea extract formulated in softgel capsules. C, et al. Eur J Pharm Biopharm. 2015 Nov;97(Pt A):8-14. doi: 10.1016/j.ejpb.2015.09.021.
  • de Sousa, A. C., Alviano, D. S., Blank, A. F., Alves, P. B., Alviano, C. S., and Gattass, C. R. Melissa officinalis L. essential oil: antitumoral and antioxidant activities. J Pharm.Pharmacol. 2004;56(5):677-681.
  • Deeb, D., Gao, X., Jiang, H., Arbab, A. S., Dulchavsky, S. A., and Gautam, S. C. Growth inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalone present in hops, in human prostate cancer cells. Anticancer Res 2010;30(9):3333-3339.
  • Di, Viesti, V, Carnevale, G., Zavatti, M., Benelli, A., and Zanoli, P. Increased sexual motivation in female rats treated with Humulus lupulus L. extract. J Ethnopharmacol. 3-24-2011;134(2):514-517.
  • Dimitrova, Z., Dimov, B., Manolova, N., Pancheva, S., Ilieva, D., and Shishkov, S. Antiherpes effect of Melissa officinalis L. extracts. Acta Microbiol Bulg. 1993;29:65-72.
  • Dimpfel W, Suter A. Sleep improving effects of a single dose administration of a valerian/hops fluid extract – a double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using electrohypnograms. Eur J Med Res 2008;13:200-4.
  • Dixon-Shanies D, Shaikh N. Growth inhibition of human breast cancer cells by herbs and phytoestrogens. Oncol Rep 1999;6:1383-7.
  • Dkbas, N., Bagc, E., Kotan, R., Cakmakc, R., Ozer, H., Mete, E., and Erdogan, G. Comparative antibacterial activities and chemical composition of some plants’ oils against Salmonella enteritidis. Research on Crops 2010;11(1):118-124.

Dorn, C., Kraus, B., Motyl, M., Weiss, T. S., Gehrig, M., Scholmerich, J., Heilmann, J., and Hellerbrand, C. Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis. Mol Nutr Food Res 2010;54 Suppl 2:S205-S213.

  • Dorn, C., Weiss, T. S., Heilmann, J., and Hellerbrand, C. Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells. Int J Oncol. 2010;36(2):435-441.
  • Dressing H, Kohler S, and Muller WE. Improvement in sleep quality with a high dose valerian-melissa preparation . Psychopharmakotherapie 1996;3:123-130.
  • Dressing H. Valerian combination therapy vs. benzodiazepine: same efficacy in the treatment of sleeping disorders? Therapiewoche 1992;42(12):726-736.
  • Drozd, J. and Anuszewska, E. The effect of the Melissa officinalis extract on immune response in mice. Acta Pol.Pharm. 2003;60(6):467-470.
  • Dumas, E. R., Michaud, A. E., Bergeron, C., Lafrance, J. L., Mortillo, S., and Gafner, S. Deodorant effects of a supercritical hops extract: antibacterial activity against Corynebacterium xerosis and Staphylococcus epidermidis and efficacy testing of a hops/zinc ricinoleate stick in humans through the sensory evaluation of axillary deodorancy. J Cosmet.Dermatol 2009;8(3):197-204.
  • Eady EA, Layton AM, Cove JH. A honey trap for the treatment of acne: manipulating the follicular microenvironment to control Propionibacterium acnes. Biomed Res Int. 2013;2013:679680. doi: 10.1155/2013/679680. Epub 2013 May 14. PMID: 23762853; PMCID: PMC3666392.
  • Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  • Electronic Code of Federal Regulations. Title 21. Part 182 — Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  • Electronic Code of Federal Regulations. Title 21. Part 182 — Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  • Englberger, W., Hadding, U., Etschenberg, E., Graf, E., Leyck, S., Winkelmann, J., and Parnham, M. J. Rosmarinic acid: a new inhibitor of complement C3-convertase with anti- inflammatory activity. Int J Immunopharmacol. 1988;10(6):729-737.
  • Erkkola, R., Vervarcke, S., Vansteelandt, S., Rompotti, P., De, Keukeleire D., and Heyerick, A. A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts. Phytomedicine. 2010;17(6):389-396.
  • Evans CEL. Sugars and health: a review of current evidence and future policy. Proc Nutr Soc. 2017 Aug;76(3):400-407. doi: 10.1017/S0029665116002846. Epub 2016 Dec 5. PMID: 27916004.
  • Evans JA, Johnson EJ. The role of phytonutrients in skin health. Nutrients. 2010 Aug;2(8):903-28. doi: 10.3390/nu2080903. Epub 2010 Aug 24. PMID: 22254062; PMCID: PMC3257702.
  • Fenselau, C. and Talalay, P. Is oestrogenic activity present in hops? Food Cosmet.Toxicol. 1973;11(4):597-602.
  • Franco, L., Sanchez, C., Bravo, R., Rodriguez, A. B., Barriga, C., Romero, E., and Cubero, J. The sedative effect of non-alcoholic beer in healthy female nurses. PLoS.One. 2012;7(7):e37290.
  • Fukuda T, Akiyama S, Takahashi K, Iwadate Y, Ano Y. Effect of non-alcoholic beer containing matured hop bitter acids on mood states in healthy adults: A single-arm pilot study. Nurs Health Sci 2022;24(1):7-16.
  • Fukuda T, Obara K, Saito J, Umeda S, Ano Y. Effects of hop bitter acids, bitter components in beer, on cognition in healthy adults: a randomized controlled trial. J Agric Food Chem 2020;68(1):206-12.
  • Fukuda T, Ohnuma T, Obara K, Kondo S, Arai H, Ano Y. Supplementation with Matured Hop Bitter Acids Improves Cognitive Performance and Mood State in Healthy Older Adults with Subjective Cognitive Decline. J Alzheimers Dis. 2020;76(1):387-398.
  • Gaby, A. R. Natural remedies for Herpes simplex. Altern.Med Rev. 2006;11(2):93-101.
  • Gao, X., Deeb, D., Liu, Y., Gautam, S., Dulchavsky, S. A., and Gautam, S. C. Immunomodulatory activity of xanthohumol: inhibition of T cell proliferation, cell-mediated cytotoxicity and Th1 cytokine production through suppression of NF-kappaB. Immunopharmacol.Immunotoxicol. 2009;31(3):477-484.
  • Gauruder-Burmester A, Heim S, Patz B, Seibt S. Cucurbita pepo-Rhus aromatica-Humulus lupulus combination reduces overactive bladder symptoms in women – a noninterventional study. Planta Med. 2019;85(13):1044-53.
  • Gazola, R., Machado, D., Ruggiero, C., Singi, G., and Macedo, Alexandre M. Lippia alba, Melissa officinalis and Cymbopogon citratus: effects of the aqueous extracts on the isolated hearts of rats. Pharmacol.Res 2004;50(5):477-480.
  • Gerhard, U., Linnenbrink, N., Georghiadou, C., and Hobi, V. Vigilanzmindernde Effekte zweier pflazlicher Schlafmittel (Effects of two plant-based sleep remedies on vigilance). Schweiz.Rundsch.Med.Prax. 4-9-1996;85(15):473-481.
  • Ghazizadeh J, Sadigh-Eteghad S, Marx W, et al. The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta-analysis. Phytother Res 2021;35(12):6690-6705.
  • Godnic-Cvar, J., Zuskin, E., Mustajbegovic, J., Schachter, E. N., Kanceljak, B., Macan, J., Ilic, Z., and Ebling, Z. Respiratory and immunological findings in brewery workers. Am J Ind Med 1999;35(1):68-75.
  • Goralczyk R. Beta-carotene and lung cancer in smokers: review of hypotheses and status of research. Nutr Cancer. 2009;61(6):767-74. doi: 10.1080/01635580903285155. PMID: 20155614.
  • Grant KA, McLauchlin J, Amar C. Infant botulism: advice on avoiding feeding honey to babies and other possible risk factors. Community Pract. 2013 Jul;86(7):44-6. PMID: 23914481.
  • Grodstein F, Kang JH, Glynn RJ, Cook NR, Gaziano JM. A randomized trial of beta carotene supplementation and cognitive function in men: the Physicians’ Health Study II. Arch Intern Med. 2007 Nov 12;167(20):2184-90. doi: 10.1001/archinte.167.20.2184. PMID: 17998490.
  • Guginski, G., Luiz, A. P., Silva, M. D., Massaro, M., Martins, D. F., Chaves, J., Mattos, R. W., Silveira, D., Ferreira, V. M., Calixto, J. B., and Santos, A. R. Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice. Pharmacol.Biochem.Behav. 2009;93(1):10-16.
  • Gül A, Pehlivan T. Antioxidant activities of some monofloral honey types produced across Turkey. Saudi J Biol Sci. 2018 Sep;25(6):1056-1065. doi: 10.1016/j.sjbs.2018.02.011. Epub 2018 Feb 21. PMID: 30174502; PMCID: PMC6117250.
  • Gyllenhaal, C., Merritt, S. L., Peterson, S. D., Block, K. I., and Gochenour, T. Efficacy and safety of herbal stimulants and sedatives in sleep disorders. Sleep Med Rev. 2000;4(3):229-251.
  • Hall, A. J., Babish, J. G., Darland, G. K., Carroll, B. J., Konda, V. R., Lerman, R. H., Bland, J. S., and Tripp, M. L. Safety, efficacy and anti-inflammatory activity of rho iso-alpha-acids from hops. Phytochemistry 2008;69(7):1534-1547.
  • Hanganu, D., Vlase, L., Filip, L., Sand, C., Mirel, S., and Indrei, L. L. The study of some polyphenolic compounds from Melissa officinalis L. (Lamiaceae). Rev.Med.Chir Soc.Med.Nat.Iasi 2008;112(2):525-529.
  • Hänsel R, Wohlfart R, and Schmidt H. The sedative-hypnotic principle of hops. 3. Communication: contents of 2-methyl-3-butene-2-ol in hops and hop preparations. Planta Med 1982;45:224-228.
  • Hansel, R., Wohlfart, R., and Coper, H. [Sedative-hypnotic compounds in the exhalation of hops, II]. Z.Naturforsch.[C.] 1980;35(11-12):1096-1097.
  • Hartkorn, A., Hoffmann, F., Ajamieh, H., Vogel, S., Heilmann, J., Gerbes, A. L., Vollmar, A. M., and Zahler, S. Antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury. J Nat Prod 2009;72(10):1741-1747.
  • Henderson MC, Miranda CL, Stevens JF, et al. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica 2000;30:235-51.
  • Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  • Herrmann, E. C., Jr. and Kucera, L. S. Antiviral substances in plants of the mint family (labiatae). II. Nontannin polyphenol of Melissa officinalis. Proc Soc Exp Biol Med 1967;124(3):869-874.
  • Heshmati J, Morvaridzadeh M, Sepidarkish M, et al. Effects of Melissa officinalis (Lemon Balm) on cardio-metabolic outcomes: A systematic review and meta-analysis. Phytother Res. 2020;34(12):3113-3123.
  • Heyerick, A., Vervarcke, S., Depypere, H., Bracke, M., and De Keukeleire, D. A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. Maturitas 5-20-2006;54(2):164-175.
  • Hohmann, J., Zupko, I., Redei, D., Csanyi, M., Falkay, G., Mathe, I., and Janicsak, G. Protective effects of the aerial parts of Salvia officinalis, Melissa Officinalis and Lavandula angustifolia and their constituents against enzyme-dependent and enzyme-independent lipid peroxidation. Planta Med 1999;65(6):576-578.
  • Holick, M. F., Lamb, J. J., Lerman, R. H., Konda, V. R., Darland, G., Minich, D. M., Desai, A., Chen, T. C., Austin, M., Kornberg, J., Chang, J. L., Hsi, A., Bland, J. S., and Tripp, M. L. Hop rho iso-alpha acids, berberine, vitamin D3 and vitamin K1 favorably impact biomarkers of bone turnover in postmenopausal women in a 14-week trial. J Bone Miner.Metab 2010;28(3):342-350.
  • Holtmann G, Madisch A, Juergen H, et al. A double-blind, randomized, placebo-controlled trial on the effects of an herbal preparation in patients with functional dyspepsia [Abstract]. Ann Mtg Digestive Disease Week 1999 May.
  • Holtmann, G., Madisch, A., and Juergen, H. A double-blind, randomized, placebo-controlled trial on the effects of an herbal preparation in patients with functional dyspepsia [Abstract]. Ann Mtg Digestive Disease Week 1999;May:A65.
  • Hussain, A. I., Farooq Anwar, Nigam, P. S., Sarker, S. D., Moore, J. E., Rao, J. R., and Mazumdar, A. Antibacterial activity of some Lamiaceae essential oils using resazurin as an indicator of cell growth. LWT – Food Science and Technology 2012;44(4):1199-1206.
  • Ibarra, A., Feuillere, N., Roller, M., Lesburgere, E., and Beracochea, D. Effects of chronic administration of Melissa officinalis L. extract on anxiety-like reactivity and on circadian and exploratory activities in mice. Phytomedicine. 2010;17(6):397-403.
  • Iftikhar F, Arshad M, Rasheed F, Amraiz D, Anwar P, Gulfraz M. Effects of acacia honey on wound healing in various rat models. Phytother Res. 2010 Apr;24(4):583-6. doi: 10.1002/ptr.2990. PMID: 19813239.
  • Istasse T, Jacquet N, Berchem T, Haubruge E, Nguyen BK, Richel A. Extraction of Honey Polyphenols: Method Development and Evidence of Cis Isomerization. Anal Chem Insights. 2016 Aug 10;11:49-57. doi: 10.4137/ACI.S39739. PMID: 27547032; PMCID: PMC4981221.
  • Ivanova, D., Gerova, D., Chervenkov, T., and Yankova, T. Polyphenols and antioxidant capacity of Bulgarian medicinal plants. J Ethnopharmacol 1-4-2005;96(1-2):145-150.
  • Jansen WT, Bolm M, Balling R, Chhatwal GS, Schnabel R. Hydrogen peroxide-mediated killing of Caenorhabditis elegans by Streptococcus pyogenes. Infect Immun. 2002 Sep;70(9):5202-7. doi: 10.1128/IAI.70.9.5202-5207.2002. PMID: 12183571; PMCID: PMC128270.
  • Jones, J. L., Fernandez, M. L., McIntosh, M. S., Najm, W., Calle, M. C., Kalynych, C., Vukich, C., Barona, J., Ackermann, D., Kim, J. E., Kumar, V., Lott, M., Volek, J. S., and Lerman, R. H. A Mediterranean-style low-glycemic-load diet improves variables of metabolic syndrome in women, and addition of a phytochemical-rich medical food enhances benefits on lipoprotein metabolism. J Clin Lipidol. 2011;5(3):188-196.
  • Karimi, I., Hayatgheybi, H., Razmjo, M., Yousefi, M., Dadyan, A., and Hadipour, M. Anti-hyperlipidaemic effects of an essential oil of Melissa officinalis L. in cholesterol-fed rabbits. Journal of Applied Biological Sciences 2010;4(1):17-22.
  • Kennedy DO, Little W, Haskell CF, et al. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Phytother Res. 2006 Feb;20:96-102.
  • Kennedy DO, Little W, Scholey AB. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med. 2004 Jul-Aug;66:607-13.
  • Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64.
  • Kennedy DO, Wake G, Savelev S, et al. Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology. 2003 Oct;28:1871-81.
  • Kermanshahi, R. K, Esfahani, B. N, Serkani, J. E, Asghari, G. R, and Babaie, A. A. P. The study of antibacterial effect of Humulus lupulus on some of Gram positive & Gram negative bacteria. Journal of Medicinal Plants 2009;8(30):92-97.
  • Keskn, D., Oskay, D., and Oskay, M. Antimicrobial activity of selected plant spices marketed in the West Anatolia. International Journal of Agriculture and Biology 2010;12(6):916-920.
  • Kheirkhah J, Ghorbani Z, Salari A, et al. Melissa officinalis tea favourably affects the frequency of premature ventricular beats and cardiometabolic profile among patients with premature ventricular contraction: A randomised open-label controlled trial. Int J Clin Pract 2021;75(10):e14644.
  • Kim, M. Y., Park, B. Y., Lee, H. S., Park, E. K., Hahm, J. C., Lee, J., Hong, Y., Choi, S., Park, D., Lee, H., and Yoon, M. The anti-angiogenic herbal composition Ob-X inhibits adipose tissue growth in obese mice. Int.J.Obes.(Lond) 2010;34(5):820-830.
  • Kizaibek, M., Kopp, B., Prinz, S., Popescu, R., and Upur, H. Antiproliferative activity of individual herbs of Abnormal Savda Munziq on HL-60 cells. Science & Technology Review 2009;19:94-98.
  • Kligler, B., Homel, P., Blank, A. E., Kenney, J., Levenson, H., and Merrell, W. Randomized trial of the effect of an integrative medicine approach to the management of asthma in adults on disease-related quality of life and pulmonary function. Altern.Ther.Health Med. 2011;17(1):10-15.
  • Koetter U, Schrader E, Käufeler R, et al. A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder. Phytother Res 2007;21:847-51.
  • Koetter, U and Biendl, M. HOPS. HerbalGram 2010;(87):44-57.
  • Konda, V. R., Desai, A., Darland, G., Bland, J. S., and Tripp, M. L. Rho iso-alpha acids from hops inhibit the GSK-3/NF-kappaB pathway and reduce inflammatory markers associated with bone and cartilage degradation. J Inflamm.(Lond) 2009;6:26.
  • Koytchev R, Alken RG, Dundarov S. Balm mint extract (Lo-701) for topical treatment of recurring herpes labialis. Phytomedicine 1999;6:225-30.
  • Kozłowska A, Szostak-Wegierek D. Flavonoids–food sources and health benefits. Rocz Panstw Zakl Hig. 2014;65(2):79-85. PMID: 25272572.
  • Kucera, L. S. and Herrmann, E. C., Jr. Antiviral substances in plants of the mint family (labiatae). I. Tannin of Melissa officinalis. Proc Soc Exp Biol Med 1967;124(3):865-869.
  • Kucera, L. S., Cohen, R. A., and Herrmann, E. C., Jr. Antiviral activities of extracts of the lemon balm plant. Ann N.Y.Acad Sci 7-30-1965;130(1):474-482.
  • Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. ScientificWorldJournal. 2013 Dec 29;2013:162750. doi: 10.1155/2013/162750. PMID: 24470791; PMCID: PMC3891543.
  • Lagoni, N. Wirksamkeitsprüfung eines pflanzlichen Tagessedativums in einer multizentrischen Studie. 1998;39(3):166-169.
  • Langezaal, C. R., Chandra, A., and Scheffer, J. J. Antimicrobial screening of essential oils and extracts of some Humulus lupulus L. cultivars. Pharm Weekbl Sci 12-11-1992;14(6):353-356.
  • Lara, M. S., Gutierrez, J. I., Timon, M., and Andres, A. I. Evaluation of two natural extracts (Rosmarinus officinalis L. and Melissa officinalis L.) as antioxidants in cooked pork patties packed in MAP. Meat.Sci. 2011;88(3):481-488.
  • Larrondo, J. V., Agut, M., and Calvo-Torras, M. A. Antimicrobial activity of essences from labiates. Microbios 1995;82(332):171-172.
  • Leathwood PD, Chauffard F, Heck E, Munoz-Box R. Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. Pharmacol Biochem Behav 1982;17:65-71.
  • Lee J, Chae K, Ha J, et al. Regulation of obesity and lipid disorders by herbal extracts from Morus alba, Melissa officinalis, and Artemisia capillaris in high-fat diet-induced obese mice. J Ethnopharmacol 2008;115:263-70.
  • Lee KM, Jung JS, Song DK, and et al. Effects of Humulus lupulus extract on the central nervous system in mice. Planta Med 1993;59(Suppl):A691.
  • Lee, I. S., Lim, J., Gal, J., Kang, J. C., Kim, H. J., Kang, B. Y., and Choi, H. J. Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells. Neurochem.Int 2011;58(2):153-160.
  • Lerman, R. H., Minich, D. M., Darland, G., Lamb, J. J., Chang, J. L., Hsi, A., Bland, J. S., and Tripp, M. L. Subjects with elevated LDL cholesterol and metabolic syndrome benefit from supplementation with soy protein, phytosterols, hops rho iso-alpha acids, and Acacia nilotica proanthocyanidins. J Clin Lipidol. 2010;4(1):59-68.
  • Lin JT, Chen YC, Lee YC, at al. Antioxidant, anti-proliferative and cyclooxygenase-2 inhibitory activities of ethanolic extracts from lemon balm (Melissa officinalis L.) leaves. LWT Food Sci Technol. 2012;49:1-7.
  • Lindahl O, Lindwall L. Double blind study of a valerian preparation. Pharmacol Biochem Behav. 1989 Apr;32:1065-6.
  • Liu J, Burdette JE, Xu H, et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 2001;49:2472-9.
  • Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010 Jul;4(8):118-26. doi: 10.4103/0973-7847.70902. PMID: 22228951; PMCID: PMC3249911.
  • Lopez-Jaen, A. B., Codoñer-Franch, P, Martínez-Álvarez, J. R., Villarino-Marín, A, and Valls-Bellés, V. Effect on health of non-alcohol beer and hop supplementation in a group of nuns in a closed order. Proceedings of the Nutrition Society 2010;69(OCE3):26.
  • Lukaczer D, Darland G, Tripp M, et al. A pilot trial evaluating Meta050, a proprietary combination of reduced iso-alpha acids, rosemary extract and oleanolic acid in patients with arthritis and fibromyalgia. Phytother Res 2005;19(10):864-9.
  • Lupinacci, E., Meijerink, J., Vincken, J. P., Gabriele, B., Gruppen, H., and Witkamp, R. F. Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes. J Agric Food Chem 8-26-2009;57(16):7274-7281.
  • Luzak B, Kassassir H, Roj E, Stanczyk L, Watala C, Golanski J. Xanthohumol from hop cones (Humulus lupulus L) prevents ADP-induced platelet reactivity. Arch Physiol Biochem. 2017 Feb;123(1):54-60.
  • Madisch A, Holtmann G, Mayr G, et al. Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial. Digestion 2004;69:45-52.
  • Madisch A, Melderis H, Mayr G, et al. [A plant extract and its modified preparation in functional dyspepsia. Results of a double-blind placebo controlled comparative study]. Z Gastroenterol 2001;39(7):511-7.
  • Mahmood NF, Shipman AR. The age-old problem of acne. Int J Womens Dermatol. 2016 Dec 2;3(2):71-76. doi: 10.1016/j.ijwd.2016.11.002. PMID: 28560299; PMCID: PMC5440448.
  • Mandal MD, Mandal S. Honey: its medicinal property and antibacterial activity. Asian Pac J Trop Biomed. 2011 Apr;1(2):154-60. doi: 10.1016/S2221-1691(11)60016-6. PMID: 23569748; PMCID: PMC3609166.
  • Mannering, G. J. and Shoeman, J. A. Murine cytochrome P4503A is induced by 2-methyl-3-buten-2-ol, 3-methyl- 1-pentyn-3-ol(meparfynol), and tert-amyl alcohol. Xenobiotica 1996;26(5):487-493.
  • Mannering, G. J., Shoeman, J. A., and Deloria, L. B. Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouse. Drug Metab Dispos 1992;20(2):142-147.
  • Mannering, G. J., Shoeman, J. A., and Shoeman, D. W. Effects of colupulone, a component of hops and brewers yeast, and chromium on glucose tolerance and hepatic cytochrome P450 in nondiabetic and spontaneously diabetic mice. Biochem Biophys Res Commun 5-16-1994;200(3):1455-1462.
  • Maroo N, Hazra A, Das T. Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial. Indian J Pharmacol 2013;45(1):34-9.
  • Martinelli M, Ummarino D, Giugliano FP, et al. Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) in infantile colic: an open randomized controlled trial. Neurogastroenterol Motil. 2017 Dec;29:e13145.
  • Meftahizade, H., Sargsyan, E., and Moradkhani, H. Investigation of antioxidant capacity of Melissa officinalis L. essential oils. Journal of Medicinal Plants Research 2010;4(14):1391-1395.
  • Meier S, Haschke M, Zahner C, et al. Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men – An explorative randomized placebo-controlled double-blind study. Phytomedicine. 2018 Jan 15;39:85-92.
  • Melzer J, Rosch W, Reichling J, et al. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Aliment Pharmacol Ther 2004;20:1279-87.
  • Melzer J, Schrader E, Brattström A, et al. Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial. Phytother Res. 2009 Sep;23:1303-8.
  • Mencherini, T., Picerno, P., Russo, P., Meloni, M., and Aquino, R. Composition of the fresh leaves and stems of Melissa officinalis and evaluation of skin irritation in a reconstituted human epidermis model. J.Nat.Prod. 2009;72(8):1512-1515.
  • Meolie, A. L., Rosen, C., Kristo, D., Kohrman, M., Gooneratne, N., Aguillard, R. N., Fayle, R., Troell, R., Townsend, D., Claman, D., Hoban, T., and Mahowald, M. Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence. J Clin.Sleep Med 4-15-2005;1(2):173-187.
  • Miguel MG, Antunes MD, Faleiro ML. Honey as a Complementary Medicine. Integr Med Insights. 2017 Apr 24;12:1178633717702869. doi: 10.1177/1178633717702869. PMID: 28469409; PMCID: PMC5406168.
  • Mikus, J., Harkenthal, M., Steverding, D., and Reichling, J. In vitro effect of essential oils and isolated mono- and sesquiterpenes on Leishmania major and Trypanosoma brucei. Planta Med 2000;66(4):366-368.
  • Milligan SR, Kalita JC, Heyerick A, et al. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab 1999;84:2249-52.
  • Milligan SR, Kalita JC, Pocock V, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab 2000;85:4912-5.
  • Mimica-Dukic, N., Bozin, B., Sokovic, M., and Simin, N. Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil. J Agric.Food Chem. 5-5-2004;52(9):2485-2489.
  • Minich, D. M., Lerman, R. H., Darland, G., Babish, J. G., Pacioretty, L. M., Bland, J. S., and Tripp, M. L. Hop and Acacia Phytochemicals Decreased Lipotoxicity in 3T3-L1 Adipocytes, db/db Mice, and Individuals with Metabolic Syndrome. J Nutr Metab 2010;2010
  • Miranda CL, Stevens JF, Helmrich A, et al. Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines. Food Chem Toxicol 1999;37:271-85.
  • Miranda, C. L., Yang, Y. H., Henderson, M. C., Stevens, J. F., Santana-Rios, G., Deinzer, M. L., and Buhler, D. R. Prenylflavonoids from hops inhibit the metabolic activation of the carcinogenic heterocyclic amine 2-amino-3-methylimidazo[4, 5- f]quinoline, mediated by cDNA-expressed human CYP1A2. Drug Metab Dispos 2000;28(11):1297-1302.
  • Moniruzzaman M, Sulaiman SA, Azlan SA, Gan SH. Two-year variations of phenolics, flavonoids and antioxidant contents in acacia honey. Molecules. 2013 Nov 27;18(12):14694-710. doi: 10.3390/molecules181214694. PMID: 24287998; PMCID: PMC6270151.
  • Monteiro R, Becker H, Azevedo I, Calhau C. Effect of hop (Humulus lupulus L.) flavonoids on aromatase (estrogen synthase) activity. Agric Food Chem 2006;54:2938-43.
  • Morali, G., Polatti, F., Metelitsa, E. N., Mascarucci, P., Magnani, P., and Marre, G. B. Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy. Arzneimittelforschung 2006;56(3):230-238.
  • Morin CM, Koetter U, Bastien C, et al. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep 2005;28:1465-71.
  • Mrlianova, M., Tekel’ova, D., Felklova, M., Reinohl, V., and Toth, J. The influence of the harvest cut height on the quality of the herbal drugs Melissae folium and Melissae herba. Planta Med 2002;68(2):178-180.
  • Muhammad A, Odunola OA, Ibrahim MA, Sallau AB, Erukainure OL, Aimola IA, Malami I. Potential biological activity of acacia honey. Front Biosci (Elite Ed). 2016 Jan 1;8(2):351-7. doi: 10.2741/E771. PMID: 26709666.
  • Muller SF, Klement S. A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children. Phytomedicine 2006;13:383-7.
  • Müller-Limmroth W, Ehrenstein W. [Experimental studies of the effects of Seda-Kneipp on the sleep of sleep disturbed subjects; implications for the treatment of different sleep disturbances (author’s transl)]. Med Klin. 1977 Jun 24;72:1119-25.
  • Naderi Dastjerdi M, Darooneh T, Nasiri M, Moatar F, Esmaeili S, Ozgoli G. Investigating the effect of Melissa officinalis on after-pains: A randomized single-blind clinical trial. J Caring Sci. 2019;8(3):129-138.
  • Negrao, R., Costa, R., Duarte, D., Taveira, Gomes T., Mendanha, M., Moura, L., Vasques, L., Azevedo, I., and Soares, R. Angiogenesis and inflammation signaling are targets of beer polyphenols on vascular cells. J Cell Biochem 12-1-2010;111(5):1270-1279.
  • Niculae, M., Spînu, M., Stefan, R., Sandru, C. D., Mircean, V., Brudasca, G. F., Bolfa, P., and Uricariu, R. In vitro efficacy of gentamicin and Mellisa officinalis essential oil against Pseudomonas aeruginosa isolated from dogs with otitis externa. Scientific Works – University of Agronomical Sciences and Veterinary Medicine, Bucharest Series C, Veterinary Medicine 2010;56(3/4):280-284.
  • Noguchi-Shinohara M, Hamaguchi T, Sakai K, et al. Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled Trial. J Alzheimers Dis 2022.
  • Noguchi-Shinohara M, Ono K, Hamaguchi T, et al. Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer’s disease progression. Sci Rep. 2020;10(1):18627.
  • Nozawa H. Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice. Biochem Biophys Res Commun 2005;336:754-61.
  • Ntalli, N. G., Ferrari, F., Giannakou, I., and Menkissoglu-Spiroudi, U. Phytochemistry and nematicidal activity of the essential oils from 8 Greek Lamiaceae aromatic plants and 13 terpene components. J.Agric.Food Chem. 7-14-2010;58(13):7856-7863.
  • Olas, B., Kolodziejczyk, J., Wachowicz, B., Jedrejek, D., Stochmal, A., and Oleszek, W. The extract from hop cones (Humulus lupulus) as a modulator of oxidative stress in blood platelets. Platelets. 2011;22(5):345-352.
  • Orth-Wagner, S, Ressin, WJ, and Friedrich, I. Phytosedativum gegen Schlafstörungen / Klinische Wirksamkeit und Verträglichkeit eines Phytosedativums mit Auszügen aus Baldrianwurzel, Hopfenzapfen und Melissenblättern. 1995;16(147):156.
  • Overk CR, Yao P, Chadwick LR, et al. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). J Agric Food Chem 2005;53:6246-53.
  • PARDO-ALDAVE, K. DIAZ-PIZAN M. E. VILLEGAS L. F. BERNABE E. Child behaviour modulation during first dental visit after administration of lemon balm, Poster Sessions. International Journal of Paediatric Dentistry 2009;19(1):66-170.
  • Patora, J., Majda, T., Gora, J., and Klimek, B. Variability in the content and composition of essential oil from lemon balm (Melissa officinalis L.) cultivated in Poland. Acta Pol.Pharm. 2003;60(5):395-400.
  • Peluso, M. R., Miranda, C. L., Hobbs, D. J., Proteau, R. R., and Stevens, J. F. Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2). Planta Med 2010;76(14):1536-1543.
  • Perry NSL, Menzies R, Hodgson F, et al. A randomized double-blind placebo-controlled trial of a combined extract of sage, rosemary and Melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age. Phytomedicine. 2018 Jan 15;39:42-48.
  • Perry, E. and Howes, M. J. Medicinal plants and dementia therapy: herbal hopes for brain aging? CNS.Neurosci.Ther 2011;17(6):683-698.
  • Perry, E. K., Pickering, A. T., Wang, W. W., Houghton, P. J., and Perry, N. S. Medicinal plants and Alzheimer’s disease: from ethnobotany to phytotherapy. J Pharm Pharmacol 1999;51(5):527-534.
  • Perry, E. K., Pickering, A. T., Wang, W. W., Houghton, P., and Perry, N. S. Medicinal plants and Alzheimer’s disease: Integrating ethnobotanical and contemporary scientific evidence. J Altern Complement Med 1998;4(4):419-428.
  • Philips, N., Samuel, M., Arena, R., Chen, Y. J., Conte, J., Natarajan, P., Haas, G., and Gonzalez, S. Direct inhibition of elastase and matrixmetalloproteinases and stimulation of biosynthesis of fibrillar collagens, elastin, and fibrillins by xanthohumol. J Cosmet.Sci 2010;61(2):125-132.
  • Possemiers, S., Bolca, S., Grootaert, C., Heyerick, A., Decroos, K., Dhooge, W., De, Keukeleire D., Rabot, S., Verstraete, W., and Van de Wiele, T. The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine. J Nutr 2006;136(7):1862-1867.
  • Radovic, B., Hussong, R., Gerhauser, C., Meinl, W., Frank, N., Becker, H., and Kohrle, J. Xanthohumol, a prenylated chalcone from hops, modulates hepatic expression of genes involved in thyroid hormone distribution and metabolism. Mol Nutr Food Res 2010;54 Suppl 2:S225-S235.
  • Raines, T., Jones, P., Moe, N., Duncan, R., McCall, S., and Ceremuga, T. E. Investigation of the anxiolytic effects of luteolin, a lemon balm flavonoid in the male Sprague-Dawley rat. AANA.J. 2009;77(1):33-36.
  • Ranjbar M, Salehi A, Rezaeizadeh H, et al. Efficacy of a combination of Melissa officinalis L. and Nepeta Menthoides Boiss. and Buhse on insomnia: a triple-blind, randomized placebo-controlled clinical trial. J Altern Complement Med. 2018 May 9.
  • Rojas, J., Solís, H., and Palacios, O. In vitro anti-Trypanosoma cruzi activity of essential oils of ten medicinal plants. / Evaluación in vitro de la actividad anti Trypanosoma cruzi de aceites esenciales de diez plantas medicinales.1. Anales de la Facultad de Medecina 2010;71(3):161-165.
  • Ross, S. M. Sleep disorders: a single dose administration of valerian/hops fluid extract (dormeasan) is found to be effective in improving sleep. Holist.Nurs Pract 2009;23(4):253-256.
  • Salter, S. and Brownie, S. Treating primary insomnia – the efficacy of valerian and hops. Aust.Fam.Physician 2010;39(6):433-437.
  • Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5.
  • Savino F, Cresi F, Castagno E, et al. A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare and Melissa officinalis (ColiMil) in the treatment of breastfed colicky infants. Phytother Res 2005;19:335-40.
  • Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., and Winterhoff, H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine. 2006;13(8):535-541.
  • Schmidt, U, Krieger, W, Frerick, H, and Schenk, N. Psychosomatische und psychische Störungen / Baldrian und Melisse statt synthetischer Psychopharmaka. 1992;14:15-19.
  • Schmitz M, Jäckel M. [Comparative study for assessing quality of life of patients with exogenous sleep disorders (temporary sleep onset and sleep interruption disorders) treated with a hops-valarian preparation and a benzodiazepine drug]. Wien Med Wochenschr. 1998;148:291-8.
  • Scholey A, Benson S, Gibbs A, Perry N, Sarris J, Murray G. Exploring the effects of Lactium and zizyphus complex on sleep quality: a double-blind, randomized placebo-controlled trial. Nutrients. 2017 Feb 17;9(2):E154.
  • Scholey A, et al. Anti-stress effects of lemon balm-containing foods. Nutrients. 3014;6(11):4805-4821. doi: 10.3390/nu6114805.
  • Shapouri, R and Rahnema, M. Evaluation of antimicrobial effect of hops extracts on intramacrophages Brucella abortus and B. melitensis. Jundishapur Journal of Microbiology 2011;4(Suppl 1):S51-S58.
  • Shekarriz Z, Shorofi SA, Nabati M, Shabankhani B, Yousefi SS. Effect of Melissa officinalis on systolic and diastolic blood pressures in essential hypertension: A double-blind crossover clinical trial. Phytother Res 2021;35(12):6883-6892.
  • Shirazi M, Jalalian MN, Abed M, Ghaemi M. The Effectiveness of Melissa Officinalis L. versus Citalopram on Quality of Life of Menopausal Women with Sleep Disorder: A Randomized Double-Blind Clinical Trial. Rev Bras Ginecol Obstet 2021;43(2):126-130.
  • Shou, C., Li, J., and Liu, Z. Complementary and alternative medicine in the treatment of menopausal symptoms. Chin J Integr Med 2011;17(12):883-888.
  • Simpson, W. J. and Smith, A. R. Factors affecting antibacterial activity of hop compounds and their derivatives. J Appl Bacteriol. 1992;72(4):327-334.
  • Skorska, C., Mackiewicz, B., Gora, A., Golec, M., and Dutkiewicz, J. Health effects of inhalation exposure to organic dust in hops farmers. Ann.Univ Mariae.Curie Sklodowska [Med] 2003;58(1):459-465.
  • Soh, N. L. and Walter, G. Complementary medicine for psychiatric disorders in children and adolescents. Curr.Opin.Psychiatry 2008;21(4):350-355.
  • Solberg E. The effects of powdered fertilized eggs on depression. J Med Food. 2011 Jul-Aug;14:870-5.
  • Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  • Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86.
  • St-Onge MP, Jones PJ. Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity. J Nutr 2002;132:329-32.
  • Stanojevic, D., Èomic´, L., Stefanovic´, O., and Sukdolak, S. S. In vitro synergistic antibacterial activity of Melissa officinalis L. and some preservatives. Spanish Journal of Agricultural Research 2010;8(1):109-115.
  • Stevens, J. F. and Page, J. E. Xanthohumol and related prenylflavonoids from hops and beer: to your good health! Phytochemistry 2004;65(10):1317-1330.
  • Stevens, J. F., Miranda, C. L., Frei, B., and Buhler, D. R. Inhibition of peroxynitrite-mediated LDL oxidation by prenylated flavonoids: the alpha,beta-unsaturated keto functionality of 2′-hydroxychalcones as a novel antioxidant pharmacophore. Chem Res Toxicol 2003;16(10):1277-1286.
  • Stocker HR. Sedative und hypnogene Wirkung des Hopfens. Schweizerische Brauerei-Rundschau 1967;78(4):80-89.
  • Stojanovic NM, Randjelovic PJ, Mladenovic MZ, et al. Toxic essential oils, part VI: Acute oral toxicity of lemon balm (Melissa officinalis L.) essential oil in BALB/c mice. Food Chem Toxicol. 2019;133:110794.
  • Strathmann, J., Klimo, K., Sauer, S. W., Okun, J. G., Prehn, J. H., and Gerhauser, C. Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism. FASEB J 2010;24(8):2938-2950.
  • Sun J. Morning/evening menopausal formula relieves menopausal symptoms: a pilot study. J Altern Complement Med 2003;9:403-9.
  • Swanston-Flatt, S. K., Day, C., Flatt, P. R., Gould, B. J., and Bailey, C. J. Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetes Res 1989;10(2):69-73.
  • Taguchi, Y., Takizawa, T., Ishibashi, H., Sagawa, T., Arai, R., Inoue, S., Yamaguchi, H., and Abe, S. Therapeutic effects on murine oral candidiasis by oral administration of cassia (Cinnamomum cassia) preparation. Nihon Ishinkin.Gakkai Zasshi 2010;51(1):13-21.
  • Thompson A, Meah D, Ahmed N, et al. Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome. BMC Complement Altern Med. 2013;13:338.
  • Tian F, McLaughlin JL. Bioactive flavonoids from the black locust tree, robinia pseudoacacia. Pharm Biol. 2000;38(3):229-34. doi: 10.1076/1388-0209(200007)3831-SFT229. PMID: 21214467.
  • Triantaphyllou, K., Blekas, G., and Boskou, D. Antioxidative properties of water extracts obtained from herbs of the species Lamiaceae. Int J Food Sci Nutr 2001;52(4):313-317.
  • van Breemen RB, Chen L, Tonsing-Carter A, et al. Pharmacokinetic Interactions of a Hop Dietary Supplement with Drug Metabolism in Perimenopausal and Postmenopausal Women. J Agric Food Chem. 2020;68(18):5212-5220.
  • van Hunsel, F. P. and Kampschoer, P. [Postmenopausal bleeding and dietary supplements: a possible causal relationship with hop- and soy-containing preparations]. Ned.Tijdschr.Geneeskd. 2012;156(41):A5095.
  • Van, Cleemput M., Heyerick, A., Libert, C., Swerts, K., Philippe, J., De, Keukeleire D., Haegeman, G., and De, Bosscher K. Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma. Mol Nutr Food Res 2009;53(9):1143-1155.
  • Veiskaramian A, Gholami M, Yarahmadi S, Amanolahi Baharvand P, Birjandi M. Effect of aromatherapy with Melissa essential oil on stress and hemodynamic parameters in acute coronary syndrome patients: A clinical trial in the emergency department. Complement Ther Clin Pract 2021;44:101436.
  • Vejdani R, Shalmani HR, Mir-Fattahi M, et al. The efficacy of an herbal medicine, Carmint, on the relief of abdominal pain and bloating in patients with irritable bowel syndrome: a pilot study. Dig Dis Sci. 2006 Aug;51:1501-7.
  • Vogt M, Tausch I, Wölbling RH, and et al. [Melissa extract in herpes simplex: a double-blind placebo-controlled study]. Der Allgemeinarzt 1991;13:832-841.
  • Wake, G., Court, J., Pickering, A., Lewis, R., Wilkins, R., and Perry, E. CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve failing memory. J Ethnopharmacol 2000;69(2):105-114.
  • Walker EG, Lo KR, Pahl MC, et al. An extract of hops (Humulus lupulus L.) modulates gut peptide hormone secretion and reduces energy intake in healthy-weight men: a randomized, cross-over clinical trial. Am J Clin Nutr 2022;115(3):925-940.
  • Wang S, Dunlap TL, Howell CE, et al. Hop (Humuls lupulus L.) extract and 6-prenylnaringenin induce P450 1A1 catalyzed estrogen 2-hydroxylation. Chem Res Toxicol. 2016 Jul 18;29(7):1142-50.
  • Watson K, Hatcher D, Good A. A randomised controlled trial of Lavender (Lavandula Angustifolia) and Lemon Balm (Melissa Officinalis) essential oils for the treatment of agitated behaviour in older people with and without dementia. Complement Ther Med 2019;42:366-73. doi: 10.1016/j.ctim.2018.12.016.
  • Weeks, B. S. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Med Sci Monit. 2009;15(11):RA256-RA262.
  • Weizman Z, Alkrinawi S, Goldfarb D, et al. Efficacy of herbal tea preparation in infantile colic. J Pediatr 1993;122(4):650-652.
  • Widy-Tyszkiewicz, E and Schminda, R. A randomized double blind study of sedative effects of phytotherapeutic containing valerian, hops, balm and motherwort versus placebo. Herb Polon 1997;2:154-159.
  • Wohlfart, R., Hansel, R., and Schmidt, H. [The sedative-hypnotic action of hops. 4. Communication: pharmacology of the hop substance 2-methyl-3-buten-2-ol]. Planta Med 1983;48(2):120-123.
  • Wohlfart, R., Wurm, G., Hansel, R., and Schmidt, H. [Detection of sedative-hypnotic active ingredients in hops. 5. Degradation of bitter acids to 2-methyl-3-buten-2-ol, a hop constituent with sedative-hypnotic activity]. Arch.Pharm.(Weinheim) 1983;316(2):132-137.
  • Wolbling RH and Milbradt R. [Clinical manifestations and treatment of Herpes simplex infections]. Therapiewoche 1984;34:1193-1200.
  • Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  • Wong, A. H., Smith, M., and Boon, H. S. Herbal remedies in psychiatric practice. Arch Gen.Psychiatry 1998;55(11):1033-1044.
  • Yajima, H., Ikeshima, E., Shiraki, M., Kanaya, T., Fujiwara, D., Odai, H., Tsuboyama-Kasaoka, N., Ezaki, O., Oikawa, S., and Kondo, K. Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance. J Biol Chem 8-6-2004;279(32):33456-33462.
  • Yamaguchi, N., Satoh-Yamaguchi, K., and Ono, M. In vitro evaluation of antibacterial, anticollagenase, and antioxidant activities of hop components (Humulus lupulus) addressing acne vulgaris. Phytomedicine. 2009;16(4):369-376.
  • Yamasaki, K., Nakano, M., Kawahata, T., Mori, H., Otake, T., Ueba, N., Oishi, I., Inami, R., Yamane, M., Nakamura, M., Murata, H., and Nakanishi, T. Anti-HIV-1 activity of herbs in Labiatae. Biol.Pharm Bull 1998;21(8):829-833.
  • Yargholi A, Shirbeigi L, Rahimi R, Mansouri P, Ayati MH. The effect of Melissa officinalis syrup on patients with mild to moderate psoriasis: a randomized, double-blind placebo-controlled clinical trial. BMC Res Notes 2021;14(1):253.
  • Yasukawa, K., Takeuchi, M., and Takido, M. Humulon, a bitter in the hop, inhibits tumor promotion by 12-O- tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Oncology 1995;52(2):156-158.
  • Yoon, M. and Kim, M. Y. The anti-angiogenic herbal composition Ob-X from Morus alba, Melissa officinalis, and Artemisia capillaris regulates obesity in genetically obese ob/ob mice. Pharm.Biol. 2011;49(6):614-619.
  • Zanoli, P., Zavatti, M., Rivasi, M., Benelli, A., Avallone, R., and Baraldi, M. Experimental evidence of the anaphrodisiac activity of Humulus lupulus L. in naive male rats. J Ethnopharmacol. 8-17-2009;125(1):36-40.
  • Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78.
  • Zhang, N., Liu, Z., Han, Q., Chen, J., and Lv, Y. Xanthohumol enhances antiviral effect of interferon alpha-2b against bovine viral diarrhea virus, a surrogate of hepatitis C virus. Phytomedicine. 2010;17(5):310-316.

 

CONDITIONS OF USE AND IMPORTANT INFORMATION

This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on our website. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

1 review for Serene Lemon Balm honey™

  1. Cliff Fordham

    Having suffered from anxiety for the last few years, I will try almost anything. This is natural and tastes good. I feel more relaxed.

Add a review