Yellow Butterfly™ 50g

Clinical References

Clinical evidence of the ingredients found in this product. These are public domain references and do not relate directly to our product.
Apple pieces

• Akazome, Y. Characteristics and physiological functions of polyphenols from apples. Biofactors 2004;22(1-4):311-314.
• Akamine Y, Miura M, Komori H, et al. Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers. Eur J Clin Pharmacol. 2014 Sep;70(9):1087-95.
• Anderson, J. W., Gustafson, N. J., Bryant, C. A., and Tietyen-Clark, J. Dietary fiber and diabetes: a comprehensive review and practical application. J Am Diet Assoc 1987;87(9):1189-1197.
• Asp, N. G., Agardh, C. D., Ahren, B., Dencker, I., Johansson, C. G., Lundquist, I., Nyman, M., Sartor, G., and Schersten, B. Dietary fibre in type II diabetes. Acta Med Scand Suppl 1981;656:47-50.
• Awan S, Abelleira A, Khehra L, Hieber R. Undetectable serum lithium concentrations after coadministration of liquid lithium citrate and apple juice: A case report. Ment Health Clin. 2021;11(1):27-30.
• Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
• Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2010;70:645-55.
• Balay, K. S., Hawthorne, K. M., Hicks, P. D., Griffin, I. J., Chen, Z., Westerman, M., and Abrams, S. A. Orange but not apple juice enhances ferrous fumarate absorption in small children. J Pediatr Gastroenterol Nutr 2010;50(5):545-550.
• Ballot, D., Baynes, R. D., Bothwell, T. H., Gillooly, M., MacFarlane, B. J., MacPhail, A. P., Lyons, G., Derman, D. P., Bezwoda, W. R., Torrance, J. D., and . The effects of fruit juices and fruits on the absorption of iron from a rice meal. Br J Nutr 1987;57(3):331-343.
• Bandazhevskaya, G. S., Nesterenko, V. B., Babenko, V. I., Yerkovich, T. V., and Bandazhevsky, Y. I. Relationship between caesium (137Cs) load, cardiovascular symptoms, and source of food in ‘Chernobyl’ children — preliminary observations after intake of oral apple pectin. Swiss.Med Wkly. 12-18-2004;134(49-50):725-729.
• Becker B, Kuhn U, Hardewig-Budny B. Double-blind, randomized evaluation of clinical efficacy and tolerability of an apple pectin-chamomile extract in children with unspecific diarrhea. Arzneimittelforschung 2006;56(6):387-393.
• Bell, J. A. and Whiting, S. J. Effect of fruit on net acid and urinary calcium excretion in an acute feeding trial of women. Nutrition 2004;20(5):492-493.
• Bondonno NP, Bondonno CP, Blekkenhorst LC, et al. Flavonoid-Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial. Mol Nutr Food Res. 2018;62(3).
• Brouns F, Theuwissen E, Adam A, Bell M, Berger A, Mensink RP. Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women. Eur J Clin Nutr. 2012 May;66(5):591-9.
• Butland BK, Fehily AM, Elwood PC. Diet and lung function decline in a cohort of 2512 middle aged men. Thorax 2000;55:102-8.
• Campbell, G., Pickles, T., and D’yachkova, Y. A randomised trial of cranberry versus apple juice in the management of urinary symptoms during external beam radiation therapy for prostate cancer. Clin Oncol.(R.Coll Radiol.) 2003;15(6):322-328.
• Castillo-Zamora, C., Castillo-Peralta, L. A., and Nava-Ocampo, A. A. Randomized trial comparing overnight preoperative fasting period Vs oral administration of apple juice at 06:00-06:30 am in pediatric orthopedic surgical patients. Paediatr.Anaesth. 2005;15(8):638-642.
• Castleman M. The healing herbs, the ultimate guide to the curative power of nature’s medicines. 2nd ed. New York, NY: Bantam Books, 1995.
• Chai SC, Hooshmand S, Saadat RL, Payton ME, Brummel-Smith K, Arjmandi BH. Daily apple versus dried plum: impact on cardiovascular disease risk factors in postmenopausal women. J Acad Nutr Diet. 2012 Aug;112(8):1158-68.
• Conceição de Oliveira M, Sichieri R, Sanchez Moura A. Weight loss associated with a daily intake of three apples or three pears among overweight women. Nutrition 2003;19:253-6.
• Cummings, J. H., Branch, W., Jenkins, D. J., Southgate, D. A., Houston, H., and James, W. P. Colonic response to dietary fibre from carrot, cabbage, apple, bran. Lancet 1978;1(8054):5-9.
• Davidson MH, Dugan LD, Stocki J, et al. A low-viscosity soluble-fiber fruit juice supplement fails to lower cholesterol in hypercholesterolemic men and women. J Nutr 1998;128:1927-32.
• de la Motte S, Bose-O’Reilly S, Heinisch M, Harrison F. [Double-blind comparison of an apple pectin-chamomile extract preparation with placebo in children with diarrhea]. Arzneimittelforschung 1997;47(11):1247-1249.
• Dekkers R. Apple juice and the chemical-contact softening of gallstones. Lancet 1999;354:2171.
• Enomoto, T., Nagasako-Akazome, Y., Kanda, T., Ikeda, M., and Dake, Y. Clinical effects of apple polyphenols on persistent allergic rhinitis: A randomized double-blind placebo-controlled parallel arm study. J Investig.Allergol.Clin Immunol. 2006;16(5):283-289.
• Francini A, Sebastiani L. Phenolic Compounds in Apple (Malus x domestica Borkh.): Compounds Characterization and Stability during Postharvest and after Processing. Antioxidants (Basel). 2013 Sep 18;2(3):181-93.
• Gallus, S., Talamini, R., Giacosa, A., Montella, M., Ramazzotti, V., Franceschi, S., Negri, E., and La, Vecchia C. Does an apple a day keep the oncologist away? Ann Oncol. 2005;16(11):1841-1844.
• Greenblatt DJ. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 2009;49:1403-7.
• Hoekstra, J. H., van den Aker, J. H., Ghoos, Y. F., Hartemink, R., and Kneepkens, C. M. Fluid intake and industrial processing in apple juice induced chronic non-specific diarrhoea. Arch Dis Child 1995;73(2):126-130.
• Hollands WJ, Hart DJ, Dainty JR,et al. Bioavailability of epicatechin and effects on nitric oxide metabolites of an apple flavanol-rich extract supplemented beverage compared to a whole apple puree: a randomized, placebo-controlled, crossover trial. Mol Nutr Food Res. 2013 Jul;57(7):1209-17.
• Howell, A. B., Reed, J. D., Krueger, C. G., Winterbottom, R., Cunningham, D. G., and Leahy, M. A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Phytochemistry 2005;66(18):2281-2291.
• Jeon H, Jang IJ, Lee S, et al. Apple juice greatly reduces systemic exposure to atenolol. Br J Clin Pharmacol 2012 May 11. doi: 10.1111/j.1365-2125.2012.04324.x.
• Joy JM, Falcone PH, Vogel RM, Mosman MM, Kim MP, Moon JR. Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affecting hematology in resistance-trained men. Appl Physiol Nutr Metab. 2015 Nov;40(11):1171-7.
• Joy JM, Vogel RM, Moon JR, et al.Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men. BMC Complement Altern Med. 2016 Jul 18;16:224.
• Kamath AV, Yao M, Zhang Y, Chong S. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 2005;94:233-9.
• Kamimura, A., Takahashi, T., and Watanabe, Y. Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent. Phytomedicine. 2000;7(6):529-536.
• Kang, J. Y., Tay, H. H., Guan, R., Math, M. V., Yap, I., and Labrooy, S. J. Dietary supplementation with pectin in the maintenance treatment of duodenal ulcer. A controlled study. Scand J Gastroenterol 1988;23(1):95-99.
• Ko, S. H., Choi, S. W., Ye, S. K., Cho, B. L., Kim, H. S., and Chung, M. H. Comparison of the antioxidant activities of nine different fruits in human plasma. J Med Food 2005;8(1):41-46.
• Kopac P, Rudin M, Gentinetta T, et al. Continuous apple consumption induces oral tolerance in birch-pollen-associated apple allergy. Allergy. 2012 Feb;67(2):280-5.
• Krishnasamy S, Lomer MCE, Marciani L, et al. Processing apples to puree or juice speeds gastric emptying and reduces postprandial intestinal volumes and satiety in healthy adults. J Nutr 2020;150(11):2890-9.
• Kunkel SD. Elmore CJ, Bongers KS, et al. Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. PLoS One 2012;7:e39332.
• Lazareva, E. B., Spiridonova, T. G., Chernega, E. N., Plesskaia, L. G., Grunenkova, I. V., Smirnov, S. V., and Men’shikov, D. D. [Topical pectins for the treatment of burn wounds]. Antibiot.Khimioter. 2002;47(9):9-13.
• Le Marchand L, Murphy SP, Hankin JH, et al. Intake of flavonoids and lung cancer. J Natl Cancer Inst 2000;92:154-60.
• Liddle DM, Lin X, Cox LC, et al. Daily apple consumption reduces plasma and peripheral blood mononuclear cell-secreted inflammatory biomarkers in adults with overweight and obesity: a 6-week randomized, controlled, parallel-arm trial. Am J Clin Nutr 2021;114(2):752-763.
• Liddle DM, Lin X, Ward EM, Cox LC, Wright AJ, Robinson LE. Apple consumption reduces markers of postprandial inflammation following a high fat meal in overweight and obese adults: A randomized, crossover trial. Food Funct 2021;12(14):6348-6362.
• Luo J, Imai H, Ohyama T, et al. The Pharmacokinetic Exposure to Fexofenadine is Volume-Dependently Reduced in Healthy Subjects Following Oral Administration With Apple Juice. Clin Transl Sci. 2016 Aug;9(4):201-6.
• Lust J. The herb book. New York, NY: Bantam Books, 1999.
• Maekawa, N., Mikawa, K., Yaku, H., Nishina, K., and Obara, H. Effects of 2-, 4- and 12-hour fasting intervals on preoperative gastric fluid pH and volume, and plasma glucose and lipid homeostasis in children. Acta Anaesthesiol.Scand 1993;37(8):783-787.
• Mahalko JR, Sandstead HH, Johnson LK, et al. Effect of consuming fiber from corn bran, soy hulls, or apple powder on glucose tolerance and plasma lipids in type II diabetes. Am J Clin Nutr 1984;39:25-34.
• Mayer, B., Schumacher, M., Brandstatter, H., Wagner, F. S., and Hermetter, A. High-throughput fluorescence screening of antioxidative capacity in human serum. Anal.Biochem 10-15-2001;297(2):144-153.
• Mayne, P. D., McGill, A. R., Gormley, T. R., Tomkin, G. H., Julian, T. R., and O’Moore, R. R. The effect of apple fibre on diabetic control and plasma lipids. Ir J Med Sci 1982;151(2):36-41.
• Mee, K. A. and Gee, D. L. Apple fiber and gum arabic lowers total and low-density lipoprotein cholesterol levels in men with mild hypercholesterolemia. J Am Diet Assoc 1997;97(4):422-424.
• Naguib, M., Samarkandimb, A. H., Al-Hattab, Y., Turkistani, A., Delvi, M. B., Riad, W., and Attia, M. Metabolic, hormonal and gastric fluid and pH changes after different preoperative feeding regimens. Can J Anaesth. 2001;48(4):344-350.
• Nesterenko, V. B., Nesterenko, A. V., Babenko, V. I., Yerkovich, T. V., and Babenko, I. V. Reducing the 137Cs-load in the organism of “Chernobyl” children with apple-pectin. Swiss.Med Wkly. 1-10-2004;134(1-2):24-27.
• Paut, O. and Camboulives, J. [Perioperative fasting in children: current data]. Arch Pediatr 1995;2(8):774-782.
• Pirich, C., Schmid, P., Pidlich, J., and Sinzinger, H. [Lowering cholesterol with Anticholest–a high fiber guar-apple pectin drink]. Wien.Klin Wochenschr. 1992;104(11):314-316.
• Rabbani GH, Teka T, Zaman B, et al. Clinical studies in persistent diarrhea: dietary management with green banana or pectin in Bangladeshi children. Gastroenterology 2001;121:554-60.
• Remington R, Chan A, Lepore A, Kotlya E, Shea TB. Apple juice improved behavioral but not cognitive symptoms in moderate-to-late stage Alzheimer’s disease in an open-label pilot study. Am J Alzheimers Dis Other Demen. 2010 Jun;25(4):367-71.
• Rodriguez J, Crespo JF, Lopez-Rubio A, et al. Clinical cross-reactivity among foods of the Rosaceae family. J Allergy Clin Immunol 2000;106:183-189.
• Rubido S, García-Caballero L, Abeleira MT, Limeres J, García M, Diz P. Effect of chewing an apple on dental plaque removal and on salivary bacterial viability. PLoS One. 2018;13(7):e0199812.
• Sansone K, Kern M, Hong MY, Liu C, Hooshmand S. Acute Effects of Dried Apple Consumption on Metabolic and Cognitive Responses in Healthy Individuals. J Med Food. 2018;21(11):1158-1164.
• Shah, M., Griffin, I. J., Lifschitz, C. H., and Abrams, S. A. Effect of orange and apple juices on iron absorption in children. Arch Pediatr Adolesc Med 2003;157(12):1232-1236.
• Sobolev, M. B., Khatskel’, S. B., and Muradov, A. I. [Enterosorption by nonstarch polysaccharides as a method of treatment of children with mercury poisoning]. Vopr.Pitan. 1999;68(1):28-30.
• Soriano-Maldonado A, Hidalgo M, Arteaga P, de Pascual-Teresa S, Nova E. Effects of regular consumption of vitamin C-rich or polyphenol-rich apple juice on cardiometabolic markers in healthy adults: a randomized crossover trial. Eur J Nutr. 2014 Dec;53(8):1645-57.
• Splinter, W. M., Stewart, J. A., and Muir, J. G. Large volumes of apple juice preoperatively do not affect gastric pH and volume in children. Can J Anaesth. 1990;37(1):36-39.
• Splinter, W. M., Stewart, J. A., and Muir, J. G. The effect of preoperative apple juice on gastric contents, thirst, and hunger in children. Can J Anaesth. 1989;36(1):55-58.
• Takahashi, T., Kamimura, A., Yokoo, Y., Honda, S., and Watanabe, Y. The first clinical trial of topical application of procyanidin B-2 to investigate its potential as a hair growing agent. Phytother.Res 2001;15(4):331-336.
• Tanabe, T., Ebina, M., Ishihara, H., Matsuki, A., Oshima, S., and Fukushi, S. [Preanesthetic meals in elective surgical patients]. Masui 1997;46(6):788-792.
• Tanabe, T., Hashimoto, Y., Sugihara, K., Miyata, A., Maeda, A., Ishihara, H., and Matsuki, A. [The effect of preoperative oral fluid intake on the volume and pH of gastric contents in elective surgical patients–a comparison of tea with apple juice]. Masui 1996;45(8):967-970.
• Tapaninen T, Neuvonen PJ, Niemi M. Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren. Br J Clin Pharmacol 2011;71:718-26.
• Tsiougkos N, Vovolis V. Repeated anaphylactic episodes to orange and apple. Eur Ann Allergy Clin Immunol. 2013 May;45(3):113-5.
• Valenkevich, L. N. [Apple powder in the treatment of patients with chronic enteritis]. Vopr.Pitan. 1993;(3):24-27.
• Valois, S., Costa-Ribeiro, H., Jr., Mattos, A., Ribeiro, T. C., Mendes, C. M., and Lifshitz, F. Controlled, double-blind, randomized clinical trial to evaluate the impact of fruit juice consumption on the evolution of infants with acute diarrhea. Nutr J 2005;4:23.
• Visvanathan, R., Chen, R., Horowitz, M., and Chapman, I. Blood pressure responses in healthy older people to 50 g carbohydrate drinks with differing glycaemic effects. Br J Nutr 2004;92(2):335-340.
• Wruss J, Lanzerstorfer P, Huemer S, et al. Differences in pharmacokinetics of apple polyphenols after standardized oral consumption of unprocessed apple juice. Nutr J. 2015 Apr 1;14:32.
• Yaneva, M. P., Botushanova, A. D., Grigorov, L. A., Kokov, J. L., Todorova, E. P., and Krachanova, M. G. Evaluation of the immunomodulatory activity of Aronia in combination with apple pectin in patients with breast cancer undergoing postoperative radiation therapy. Folia Med (Plovdiv.) 2002;44(1-2):22-25.
• Young, J. F., Nielsen, S. E., Haraldsdottir, J., Daneshvar, B., Lauridsen, S. T., Knuthsen, P., Crozier, A., Sandstrom, B., and Dragsted, L. O. Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status. Am J Clin Nutr 1999;69(1):87-94.

Elderflower

• Anon. Elderberry (Sambucus species). The Poison Plant Patch, Novia Scotia Museum, 2007. Available at: https://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009).
• Chrubasik C, Maier T, Dawid C, et al. An observational study and quantification of the actives in a supplement with Sambucus nigra and Asparagus officinalis used for weight reduction. Phytother Res 2008;22:913-8.
• Cunha S, Meireles D, Machado J. Sambucus nigra – a promising natural source for human health. Exp Pathol Health Sci. 2016;8(2):59-66.
• Electronic Code of Federal Regulations. Title 21. Part 182 — Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
• European elder. Canadian Poisonous Plants Information System. Available at: https://www.cbif.gc.ca/pls/pp/ppack.jump?p_null=all&p_psn=121&p_type=all&p_sci=comm&p_x=px (Accessed 16 October 2009).
• Forster-Waldl E, Marchetti M, Scholl I, Focke M, et al. Type I allergy to elderberry (Sambucus nigra) is elicited by a 33.2 kDa allergen with significant homology to ribosomal inactivating proteins. Clin Exp Allergy 2003;33:1703-10.
• Gray AM, Abdel-Wahab YH, Flatt PR. The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro. J Nutr 2000;130:15-20.
• Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
• Melzer, J., Saller, R., Schapowal, A., and Brignoli, R. Systematic review of clinical data with BNO-101 (Sinupret) in the treatment of sinusitis. Forsch Komplement.Med (2006.) 2006;13(2):78-87.
• Mikulic-Petkovsek M, Samoticha J, Eler K, Stampar F, Veberic R. Traditional elderflower beverages: a rich source of phenolic compounds with high antioxidant activity. J Agric Food Chem. 2015;63(5):1477-87.
• Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
• Peric A, Kovacevic SV, Gacesa D, Peric AV. Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray. ENT Updates 2017;7(2):68-74.
• Picon, P. D., Picon, R. V., Costa, A. F., Sander, G. B., Amaral, K. M., Aboy, A. L., and Henriques, A. T. Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation. BMC.Complement Altern.Med. 2010;10:17.
• Viapiana A, Wesolowski M. The phenolic contents and antioxidant activities of infusions of Sambucus nigra L. Plant Foods Hum Nutr. 2017;72(1):82-7.
• Vlachojannis JE, Cameron M, Chrubasik S. A systematic review on the sambuci fructus effect and efficacy profiles. Phytother Res. 2010 Jan;24(1):1-8.

Ginger

• Abdel Halim, A. S. Efficacy of Zingiber officinale on third stage larvae and adult fecundity of Musca domestica and Anopheles pharoensis. J Egypt Soc.Parasitol. 2008;38(2):385-392.
• Abdel-Aziz, H., Nahrstedt, A., Petereit, F., Windeck, T., Ploch, M., and Verspohl, E. J. 5-HT3 receptor blocking activity of arylalkanes isolated from the rhizome of Zingiber officinale. Planta Med 2005;71(7):609-616.
• Abdel-Aziz, H., Windeck, T., Ploch, M., and Verspohl, E. J. Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. Eur.J Pharmacol. 1-13-2006;530(1-2):136-143.
• Abebe W. Herbal medication: potential for adverse interactions with analgesic drugs. J Clin Pharm Ther. 2002;27:391-401.
• Adib Rad H, Basirat Z, Bakouei F, et al. Effect of Ginger and Novafen on menstrual pain: A cross-over trial. Taiwan J Obstet Gynecol. 2018 Dec;57(6):806-809. doi: 10.1016/j.tjog.2018.10.006.
• Aeschbach R, Loliger J, Scott BC. Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem Toxicol 1994;32:31-6.
• Ahad A, Raish M, Bin Jardan YA, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effect of Hibiscus sabdariffa and Zingiber officinale on the antihypertensive activity and pharmacokinetic of losartan in hypertensive rats. Xenobiotica. 2020:1-11.
• Ahui, M. L., Champy, P., Ramadan, A., Pham, Van L., Araujo, L., Brou, Andre K., Diem, S., Damotte, D., Kati-Coulibaly, S., Offoumou, M. A., Dy, M., Thieblemont, N., and Herbelin, A. Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation. Int Immunopharmacol. 12-10-2008;8(12):1626-1632.
• Akbarzadeh E, Heydari M, Atarzadeh F, Jaladat AM. Chronic dysuria following ginger (Zingiber officinale) use: a case report. Galen Med J 2018;7:e1086.
• Akhani SP, Vishwakarma SL, Goyal RK. Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats. J Pharm Pharmacol 2004;56:101-5.
• Aktan, F., Henness, S., Tran, V. H., Duke, C. C., Roufogalis, B. D., and Ammit, A. J. Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity. Planta Med 2006;72(8):727-734.
• al Yahya, M. A., Rafatullah, S., Mossa, J. S., Ageel, A. M., Parmar, N. S., and Tariq, M. Gastroprotective activity of ginger zingiber officinale rosc., in albino rats. Am.J Chin Med. 1989;17(1-2):51-56.
• Al-Amin ZM, Thomson M, Al-Qattan KK, et al. Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. Br J Nutr. 2006;96:660-6.
• Alam MA, Bin Jardan YA, Alzenaidy B, et al. Effect of Hibiscus sabdariffa and Zingiber officinale on pharmacokinetics and pharmacodynamics of amlodipine. J Pharm Pharmacol 2021;73(9):1151-60.
• Alizadeh-Navaei R, Roozbeh F, Saravi M, et al. Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial. Saudi Med J. 2008;29:1280-4.
• Altman RD, Marcussen KC. Effects of ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum 2001;44:2531-38.
• Alzoreky, N. S. and Nakahara, K. Antibacterial activity of extracts from some edible plants commonly consumed in Asia. Int J Food Microbiol. 2-15-2003;80(3):223-230.
• Amorndoljai P, Taneepanichskul S, Niempoog S, Nimmannit U. A Comparative of Ginger Extract in Nanostructure Lipid Carrier (NLC) and 1% Diclofenac Gel for Treatment of Knee Osteoarthritis (OA). J Med Assoc Thai. 2017;100(4):447-56.
• Amorndoljai P, Taneepanichskul S, Niempoog S, Nimmannit U. Improving of Knee Osteoarthritic Symptom by the Local Application of Ginger Extract Nanoparticles: A Preliminary Report with Short Term Follow-Up. J Med Assoc Thai. 2015;98(9):871-7.
• Anon. Case problem: presenting conventional and complementary approaches for relieving nausea in a breast cancer patient undergoing chemotherapy. J Am Diet Assoc 2000;100:257-9.
• Ansari M, Porouhan P, Mohammadianpanah M, et al. Efficacy of ginger in control of chemotherapy induced nausea and vomiting in breast cancer patients receiving doxorubicin-based chemotherapy. Asian Pac J Cancer Prev. 2016;17(8):3877-80.
• Ansari, M. N., Bhandari, U., and Pillai, K. K. Ethanolic Zingiber officinale R. extract pretreatment alleviates isoproterenol-induced oxidative myocardial necrosis in rats. Indian J Exp.Biol. 2006;44(11):892-897.
• Apariman S, Ratchanon S, Wiriyasirivej B. Effectiveness of ginger for prevention of nausea and vomiting after gynecological laparoscopy. J Med Assoc Thai. 2006;89:2003-9.
• Araya-Quintanilla F, Gutierrez-Espinoza H, Munoz-Yanez MJ, Sanchez-Montoya U, Lopez-Jeldes J. Effectiveness of ginger on pain and function in knee osteoarthritis: A PRISMA systematic review and meta-analysis. Pain Physician. 2020;23(2):E151-E161.
• Arfeen Z, Owen H, Plummer JL, et al. A double-blind randomized controlled trial of ginger for the prevention of postoperative nausea and vomiting. Anaesth Intensive Care 1995;23:449-52.
• Argento A, Tiraferri E, Marzaloni M. [Oral anticoagulants and medicinal plants. An emerging interaction]. Ann Ital Med Int. 2000;15:139-43.
• Arslan M, Ozdemir L. Oral intake of ginger for chemotherapy-induced nausea and vomiting among women with breast cancer. Clin J Oncol Nurs. 2015;19(5):E92-7.
• Aryaeian N, Mahmoudi M, Shahram F, Poursani S, Jamshidi F, Tavakoli H. The effect of ginger supplementation on IL2, TNFα, and IL1β cytokines gene expression levels in patients with active rheumatoid arthritis: A randomized controlled trial. Med J Islam Repub Iran. 2019;33:154.
• Aryaeian N, Shahram F, Mahmoudi M, et al. The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active rheumatoid arthritis. Gene 2019;698:179-85.
• Asghari-Jafarabadi M, Khalili L. The Effect of Ginger (Zingiber officinale) on Improving Blood Lipids and Body Weight; A Systematic Review and Multivariate Meta-analysis of Clinical Trials. Curr Pharm Des 2022.
• Ashraf H, Heydari M, Shams M, Zarshenas MM, Tavakoli A, Sayadi M. Efficacy of ginger supplementation in relieving persistent hypothyroid symptoms in patients with controlled primary hypothyroidism: a pilot randomized, double-blind, placebo-controlled clinical trial. Evid Based Complement Alternat Med 2022;2022:5456855.
• Asnani, V. and Verma, R. J. Antioxidative effect of rhizome of Zinziber officinale on paraben induced lipid peroxidation: an in vitro study. Acta Pol.Pharm. 2007;64(1):35-37.
• Asnani, V. M. and Verma, R. J. Ameliorative effects of ginger extract on paraben-induced lipid peroxidation in the liver of mice. Acta Pol.Pharm. 2009;66(3):225-228.
• Azimi P, Ghiasvand R, Feizi A, et al. Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trial. Blood Press. 2016;25(3):133-40.
• Backon J. Ginger as an antiemetic: possible side effects due to its thromboxane synthetase activity. Anaesthesia. 1991;46(8):705-6..
• Backon J. Ginger in preventing nausea and vomiting of pregnancy; a caveat due to its thromboxane synthetase activity and effect on testosterone binding. Eur J Obstet Gynecol Reprod Biol 1991;42:163-4.
• Badooei F, Imani E, Hosseini-Teshnizi S, Banar M, Memarzade M. Comparison of the effect of ginger and aloe vera mouthwashes on xerostomia in patients with type 2 diabetes: A clinical trial, triple-blind. Med Oral Patol Oral Cir Bucal 2021;26(4):e408-e413.
• Bartels EM, Folmer VN, Bliddal H, et al. Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials. Osteoarthritis Cartilage. 2015;23(1):13-21.
• Bhandari U, Kanojia R, Pillai KK. Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. J Ethnopharmacol. 2005;97:227-30.
• Bhandari, U., Sharma, J. N., and Zafar, R. The protective action of ethanolic ginger (Zingiber officinale) extract in cholesterol fed rabbits. J Ethnopharmacol. 1998;61(2):167-171.
• Bhargava R, Chasen M, Elten M, MacDonald N. The effect of ginger (Zingiber officinale Roscoe) in patients with advanced cancer. Support Care Cancer. 2019.
• Black CD, Herring MP, Hurley DJ, O’Connor PJ. Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. J Pain 2010;11:894-903.
• Black CD, O’Connor PJ. Acute effects of dietary ginger on muscle pain induced by eccentric exercise. Phytother Res 2010;24:1620-6.
• Black CD, O’Connor PJ. Acute effects of dietary ginger on quadriceps muscle pain during moderate-intensity cycling exercise. Int J Sport Nutr Exerc Metab 2008;18:653-64.
• Bliddal H, Rosetzsky A, Schlichting P, et al. A randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis. Osteoarthritis Cartilage 2000;8:9-12.
• Bone ME, Wilkinson DJ, Young JR, et al. Ginger root-a new antiemetic. The effect of ginger root on postoperative nausea and vomiting after major gynaecological surgery. Anaesthesia 1990;45:669-71.
• Borrelli F, Capasso R, Aviello G, et al. Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Obstet Gynecol 2005;105:849-56.
• Bossi P, Cortinovis D, Fatigoni S, et al. A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin. Ann Oncol. 2017;28(10):2547-2551.
• Braga Tibaes JR, Martins LB, Rodrigues AMDS, Amaral MHA, Teixeira AL, Ferreira AVM. Ginger supplementation does not increase energy expenditure in female adults. Nutrition 2022;103-104:111803.
• Brockwell C, Ampikaipakan S, Sexton DW, Price D, Freeman D, Thomas M, Ali M, Wilson AM. Adjunctive treatment with oral AKL1, a botanical nutraceutical, in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2014;9:715-21.
• Cady RK, Goldstein J, Nett R, et al. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic M) in the treatment of migraine. Headache 2011;51:1078-86.
• Cady RK, Schreiber CP, Beach ME, et al. Gelstat Migraine (sublingually administered feverfew and ginger compound) for acute treatment of migraine when administered during the mild pain phase. Med Sci Monit. 2005;11:I65-69.
• Calvert I. Ginger: an essential oil for shortening labour? Pract Midwife. 2005;8:30-4.
• Chaiyakunapruk N, Kitikannakorn N, Nathisuwan S, et al. The efficacy of ginger for the prevention of postoperative nausea and vomiting: a meta-analysis. Am J Obstet Gynecol 2006;194:95-9.
• Chang WP, Peng YX. Does the Oral Administration of Ginger Reduce Chemotherapy-Induced Nausea and Vomiting?: A Meta-analysis of 10 Randomized Controlled Trials. Cancer Nurs. 2019;42(6):E14-E23.
• Chiang HM, Chao PD, Hsiu SL, et al. Ginger significantly decreased the oral bioavailability of cyclosporine in rats. Am J Chin Med. 2006;34:845-55.
• Chitre D, Nadkarni S, Jagtap N, et al. Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers. Phytother Res 2022.
• Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
• Choi JS, Han JY, Ahn HK, et al. Assessment of fetal and neonatal outcomes in the offspring of women who had been treated with dried ginger (Zingiberis rhizoma siccus) for a variety of illnesses during pregnancy. J Obstet Gynaecol. 2015;35(2):125-30.
• Chopra A, Saluja M, Tillu G, Sarmukkaddam S, Venugopalan A, Narsimulu G, Handa R, Sumantran V, Raut A, Bichile L, Joshi K, Patwardhan B. Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trial. Rheumatology (Oxford) 2013;52(8):1408-17.
• Chung, S. W., Kim, M. K., Chung, J. H., Kim, D. H., Choi, J. S., Anton, S., Seo, A. Y., Park, K. Y., Yokozawa, T., Rhee, S. H., Yu, B. P., and Chung, H. Y. Peroxisome proliferator-activated receptor activation by a short-term feeding of zingerone in aged rats. J Med Food 2009;12(2):345-350.
• Crichton M, Marshall S, Marx W, McCarthy AL, Isenring E. Efficacy of ginger (Zingiber officinale) in ameliorating chemotherapy-induced nausea and vomiting and chemotherapy-related outcomes: A systematic review update and meta-analysis. J Acad Nutr Diet. 2019;119(12):2055-2068.
• Cwikla, C., Schmidt, K., Matthias, A., Bone, K. M., Lehmann, R., and Tiralongo, E. Investigations into the antibacterial activities of phytotherapeutics against Helicobacter pylori and Campylobacter jejuni. Phytother.Res 2010;24(5):649-656.
• Dabaghzadeh F, Khalili H, Dashti-Khavidaki S, Abbasian L, Moeinifard A. Ginger for prevention of antiretroviral-induced nausea and vomiting: a randomized clinical trial. Expert Opin Drug Saf 2014;13(7):859-66.
• Daily JW, Zhang X, Kim da S, et al. Efficacy of Ginger for Alleviating the Symptoms of Primary Dysmenorrhea: A Systematic Review and Meta-analysis of Randomized Clinical Trials. Pain Med. 2015;16(12):2243-55.
• Dastgheib M, Barati-Boldaji R, Bahrampour N, et al. A comparison of the effects of cinnamon, ginger, and metformin consumption on metabolic health, anthropometric indices, and sexual hormone levels in women with poly cystic ovary syndrome: A randomized double-blinded placebo-controlled clinical trial. Front Nutr. 2022 Nov 29;9:1071515.
• Dominguez-Balmaseda D, Diez-Vega I, Larrosa M, et al. Effect of a Blend of Zingiber officinale Roscoe and Bixa orellana L. Herbal Supplement on the Recovery of Delayed-Onset Muscle Soreness Induced by Unaccustomed Eccentric Resistance Training: A Randomized, Triple-Blind, Placebo-Controlled Trial. Front Physiol. 2020;11:826.
• Drozdov VN, Kim VA, Tkachenko EV, Varvanina GG. Influence of a specific ginger combination on gastropathy conditions in patients with osteoarthritis of the knee or hip. J Alt Compl Med 2012;18:583-8.
• Dugasani, S., Pichika, M. R., Nadarajah, V. D., Balijepalli, M. K., Tandra, S., and Korlakunta, J. N. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J.Ethnopharmacol. 2-3-2010;127(2):515-520.
• Eberhart LH, Mayer R, Betz O, et al. Ginger does not prevent postoperative nausea and vomiting after laparoscopic surgery. Anesth Analg 2003;96:995-8.
• Ebrahimzadeh A, Ebrahimzadeh A, Mirghazanfari SM, Hazrati E, Hadi S, Milajerdi A. The effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2022;65:102802.
• El Abhar, H. S., Hammad, L. N., and Gawad, H. S. Modulating effect of ginger extract on rats with ulcerative colitis. J Ethnopharmacol. 8-13-2008;118(3):367-372.
• Emrani Z, Shojaei E, Khalili H. Ginger for Prevention of Antituberculosis-induced Gastrointestinal Adverse Reactions Including Hepatotoxicity: A Randomized Pilot Clinical Trial. Phytother Res. 2016;30(6):1003-9.
• Ernst E, Pittler MH. Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. Br J Anaesth 2000;84:367-71.
• Feng XG, Hao WJ, Ding Z, et al. Clinical study on tongyan spray for post-stroke dysphagia patients: a randomized controlled trial. Chin J Integr Med. 2012;18:345-9.
• Ficker, C. E., Arnason, J. T., Vindas, P. S., Alvarez, L. P., Akpagana, K., Gbeassor, M., De Souza, C., and Smith, M. L. Inhibition of human pathogenic fungi by ethnobotanically selected plant extracts. Mycoses 2003;46(1-2):29-37.
• Ficker, C., Smith, M. L., Akpagana, K., Gbeassor, M., Zhang, J., Durst, T., Assabgui, R., and Arnason, J. T. Bioassay-guided isolation and identification of antifungal compounds from ginger. Phytother.Res. 2003;17(8):897-902.
• Fischer-Rasmussen W, Kjaer SK, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol 1991;38:19-24.
• Fouda, A. M. and Berika, M. Y. Evaluation of the effect of hydroalcoholic extract of Zingiber officinale rhizomes in rat collagen-induced arthritis. Basic Clin Pharmacol.Toxicol. 2009;104(3):262-271.
• Frondoza CG, Sohrabi A, Polotsky A, et al. An in vitro screening assay for inhibitors of proinflammatory mediators in herbal extracts using human synoviocyte cultures. In Vitro Cell Dev Biol Anim 2004;40:95-101.
• Futrell, J. M. and Rietschel, R. L. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288-290.
• Geiger J. The essential oil of ginger, Zingiber officinale, and anaesthesia. Int J Aromather 2005;15:7-14.
• Ghayur MN, Gilani AH. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. J Cardiovasc Pharmacol 2005;45:74-80.
• Ghayur, M. N. and Gilani, A. H. Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders. Dig.Dis.Sci 2005;50(10):1889-1897.
• Ghayur, M. N., Gilani, A. H., Afridi, M. B., and Houghton, P. J. Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways. Vascul.Pharmacol. 2005;43(4):234-241.
• Ghayur, M. N., Gilani, A. H., and Janssen, L. J. Ginger attenuates acetylcholine-induced contraction and Ca2+ signalling in murine airway smooth muscle cells. Can J Physiol Pharmacol. 2008;86(5):264-271.
• Greenway FL, Liu Z, Martin CK, et al. Safety and efficacy of NT, an herbal supplement, in treating human obesity. Int J Obes (Lond). 2006;30:1737-41.
• Grontved A, Brask T, Kambskard J, Hentzer E. Ginger root against seasickness: a controlled trial on the open sea. Acta Otolaryngol 1998;105:45-9.
• Grontved A, Hentzer E. Vertigo-reducing effect of ginger root. A controlled clinical study. ORL J Otorhinolaryngol Relat Spec 1986;48:282-6.
• Guh, J. H., Ko, F. N., Jong, T. T., and Teng, C. M. Antiplatelet effect of gingerol isolated from Zingiber officinale. J Pharm.Pharmacol. 1995;47(4):329-332.
• Gupta, Y. K. and Sharma, M. Reversal of pyrogallol-induced delay in gastric emptying in rats by ginger (Zingiber officinale). Methods Find.Exp.Clin Pharmacol. 2001;23(9):501-503.
• Habib, S. H., Makpol, S., Abdul, Hamid NA, Das, S., Ngah, W. Z., and Yusof, Y. A. Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats. Clinics.(Sao Paulo) 2008;63(6):807-813.
• Haghighi M, Khalva A, Toliat T, Jallaei S. Comparing the effects of ginger (Zingiber officinale) extract and ibuprofen on patients with osteoarthritis. Arch Iran Med 2005;8:267-71.
• Hajimoosayi F, Jahanian Sadatmahalleh S, Kazemnejad A, Pirjani R. Effect of ginger on the blood glucose level of women with gestational diabetes mellitus (GDM) with impaired glucose tolerance test (GTT): a randomized double-blind placebo-controlled trial. BMC Complement Med Ther. 2020;20(1):116.
• Han, L. K., Morimoto, C., Zheng, Y. N., Li, W., Asami, E., Okuda, H., and Saito, M. [Effects of zingerone on fat storage in ovariectomized rats]. Yakugaku Zasshi 2008;128(8):1195-1201.
• Heitmann K, Nordeng H, Holst L. Safety of ginger use in pregnancy: results from a large population-based cohort study. Eur J Clin Pharmacol 2012 Jun 17.
• Henning, S. M., Zhang, Y., Seeram, N. P., Lee, R. P., Wang, P., Bowerman, S., and Heber, D. Antioxidant capacity and phytochemical content of herbs and spices in dry, fresh and blended herb paste form. Int J Food Sci Nutr 2011;62(3):219-225.
• Hirata A, Funato H, Nakai M, et al. Ginger Orally Disintegrating Tablets to Improve Swallowing in Older People. Biol Pharm Bull. 2016;39(7):1107-11.
• Holtmann S, Clarke AH, Scherer H, et al. The anti-motion sickness mechanism of ginger. A comparative study with placebo and dimenhydrinate. Acta Otolaryngol. 1989;108:168-74.
• Horie, S., Yamamoto, H., Michael, G. J., Uchida, M., Belai, A., Watanabe, K., Priestley, J. V., and Murayama, T. Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats. Scand.J Gastroenterol. 2004;39(4):303-312.
• Hu ML, Rayner CK, Wu KL, et al. Effect of ginger on gastric motility and symptoms of functional dyspepsia. World J Gastroenterol. 2011;17:105-10.
• Hu Y, Amoah AN, Zhang H, et al. Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis. J Matern Fetal Neonatal Med. 2020:1-10.
• Hunt R, Dienemann J, Norton HJ, Hartley W, Hudgens A, Stern T, Divine G. Aromatherapy as treatment for postoperative nausea: a randomized trial. Anesth Analg 2013;117(3):597-604.
• Ippoushi, K., Azuma, K., Ito, H., Horie, H., and Higashio, H. [6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions. Life Sci 11-14-2003;73(26):3427-3437.
• Ippoushi, K., Ito, H., Horie, H., and Azuma, K. Mechanism of inhibition of peroxynitrite-induced oxidation and nitration by [6]-gingerol. Planta Med 2005;71(6):563-566.
• Iqbal, Z., Lateef, M., Akhtar, M. S., Ghayur, M. N., and Gilani, A. H. In vivo anthelmintic activity of ginger against gastrointestinal nematodes of sheep. J Ethnopharmacol. 6-30-2006;106(2):285-287.
• Islam MS, Choi H. Comparative effects of dietary ginger (Zingiber officinale) and garlic (Allium sativum) investigated in a type 2 diabetes model of rats. J Med Food. 2008;11:152-9.
• Janssen, P. L., Meyboom, S., van Staveren, W. A., de Vegt, F., and Katan, M. B. Consumption of ginger (Zingiber officinale roscoe) does not affect ex vivo platelet thromboxane production in humans. Eur.J Clin Nutr. 1996;50(11):772-774.
• Jenabi E. The effect of ginger for relieving of primary dysmenorrhoea. J Pak Med Assoc 2013;63(1):8-10.
• Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev 2000;(2):CD000145.
• Jiang X, Blair EY, McLachlan AJ. Investigation of the effects of herbal medicines on warfarin response in healthy subjects: a population pharmacokinetic-pharmacodynamic modeling approach. J Clin Pharmacol 2006;46:1370-8.
• Jiang X, Williams KM, Liauw WS, et al. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol 2005;59:425-32.
• Jolad, S. D., Lantz, R. C., Solyom, A. M., Chen, G. J., Bates, R. B., and Timmermann, B. N. Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production. Phytochemistry 2004;65(13):1937-1954.
• Jung, H. W., Yoon, C. H., Park, K. M., Han, H. S., and Park, Y. K. Hexane fraction of Zingiberis Rhizoma Crudus extract inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated BV2 microglial cells via the NF-kappaB pathway. Food Chem.Toxicol. 2009;47(6):1190-1197.
• Kadnur, S. V. and Goyal, R. K. Beneficial effects of Zingiber officinale Roscoe on fructose induced hyperlipidemia and hyperinsulinemia in rats. Indian J Exp.Biol. 2005;43(12):1161-1164.
• Kalava A, Darji SJ, Kalstein A, Yarmush JM, SchianodiCola J, Weinberg J. Efficacy of ginger on intraoperative and postoperative nausea and vomiting in elective cesarean section patients. Eur J Obstet Gynecol Reprod Biol 2013;169(2):184-8.
• Kamali A, Beigi S, Shokrpour M, Pazuki S. The efficacy of ginger and doxedetomidine in reducing postoperative nausea and vomiting in patients undergoing abdominal hysterectomy. Altern Ther Health Med. 2020;26(2):28-33.
• Kamtchouing, P., Mbongue Fandio, G. Y., Dimo, T., and Jatsa, H. B. Evaluation of androgenic activity of Zingiber officinale and Pentadiplandra brazzeana in male rats. Asian J Androl 2002;4(4):299-301.
• Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62.
• Kashefi F, Khajehei M, Alavinia M, Golmakani E, Asili J. Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial. Phytother Res. 2015;29(1):114-9.
• Kashefi F, Khajehei M, Tabatabaeichehr M, Alavinia M, Asili J. Comparison of the effect of ginger and zinc sulfate on primary dysmenorrhea: a placebo-controlled randomized trial. Pain Manag Nurs. 2014;15(4):826-33.
• Kazemian A, Toghiani A, Shafiei K, et al. Evaluating the efficacy of mixture of Boswellia carterii, Zingiber officinale, and Achillea millefolium on severity of symptoms, anxiety, and depression in irritable bowel syndrome patients. J Res Med Sci. 2017;22:120.
• Khodaie L, Sadeghpoor O. Ginger from ancient times to the new outlook. Jundishapur J Nat Pharm Prod 2015;10(1):e18402.
• Kim, H. W., Murakami, A., Abe, M., Ozawa, Y., Morimitsu, Y., Williams, M. V., and Ohigashi, H. Suppressive effects of mioga ginger and ginger constituents on reactive oxygen and nitrogen species generation, and the expression of inducible pro-inflammatory genes in macrophages. Antioxid.Redox.Signal. 2005;7(11-12):1621-1629.
• Koçak I, Yücepur C, Gökler O. Is Ginger Effective in Reducing Post-tonsillectomy Morbidity? A Prospective Randomised Clinical Trial. Clin Exp Otorhinolaryngol. 2018;11(1):65-70.
• Konmun J, Danwilai K, Ngamphaiboon N, Sripanidkulchai B, Sookprasert A, Subongkot S. A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy. Med Oncol. 2017;34(4):69.
• Kotowski U, Kadletz L, Schneider S, et al. 6-shogaol induces apoptosis and enhances radiosensitivity in head and neck squamous cell carcinoma cell lines. Phytother Res. 2018;32(2):340-347.
• Kruth P, Brosi E, Fux R, et al. Ginger-associated overanticoagulation by phenprocoumon. Ann Pharmacother 2004;38:257-60.
• Langner E, Greifenberg S, Gruenwald J. Ginger: history and use. Adv Ther 1998;15:25-44.
• Lantz, R. C., Chen, G. J., Sarihan, M., Solyom, A. M., Jolad, S. D., and Timmermann, B. N. The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine 2007;14(2-3):123-128.
• Leach MJ, Kumar S. The clinical effectiveness of ginger (Zingiber officinale) in adults with osteoarthritis. Int J Evid Based Healthc 2008;6:311-20.
• Lee J, Oh H. Ginger as an antiemetic modality for chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis. Oncol Nurs Forum 2013;40(2):163-70.
• Lee, T. Y., Lee, K. C., Chen, S. Y., and Chang, H. H. 6-Gingerol inhibits ROS and iNOS through the suppression of PKC-alpha and NF-kappaB pathways in lipopolysaccharide-stimulated mouse macrophages. Biochem.Biophys.Res Commun. 4-24-2009;382(1):134-139.
• Lesho EP, Saullo L, Udvari-Nagy S. A 76-year-old woman with erratic anticoagulation. Cleve Clin J Med. 2004;71:651-6.
• Li X, Qin Y, Liu W, Zhou XY, Li YN, Wang LY. Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial. Integr Cancer Ther. 2018:1534735417753541.
• Li Y, Yang D, Gao X, et al. Ginger supplement significantly reduced length of hospital stay in individuals with COVID-19. Nutr Metab (Lond). 2022 Dec 28;19(1):84.
• Lien HC, Sun WM, Chen YH, et al. Effects of ginger on motion sickness and gastric slow-wave dysrhythmias induced by circular vection. Am J Physiol Gastrointest Liver Physiol. 2003;284:G481-9.
• Liu, N., Huo, G., Zhang, L., and Zhang, X. [Effect of Zingiber OfficinaleRosc on lipid peroxidation in hyperlipidemia rats]. Wei Sheng Yan.Jiu. 2003;32(1):22-23.
• Liu, P. H. and Ho, H. L. Ginger and drug bezoar induced small bowel obstruction. J R.Coll.Surg.Edinb. 1983;28(6):397-398.
• Lohsiriwat, S., Rukkiat, M., Chaikomin, R., and Leelakusolvong, S. Effect of ginger on lower esophageal sphincter pressure. J.Med.Assoc.Thai. 2010;93(3):366-372.
• Lopez, H. L., Ziegenfuss, T. N., Hofheins, J. E., Habowski, S. M., Arent, S. M., Weir, J. P., and Ferrando, A. A. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. J Int Soc Sports Nutr 2013;10(1):22.
• Lua PL, Salihah N, Mazlan N. Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer. Complement Ther Med. 2015;23(3):396-404.
• Lumb AB. Mechanism of antiemetic effect of ginger. Anaesthesia 1993;48:1118.
• Lumb, A. B. Effect of dried ginger on human platelet function. Thromb.Haemost. 1994;71(1):110-111.
• Maenthaisong R, Chaiyakunapruk N, Tiyaboonchai W, Tawatsin A, Rojanawiwat A, Thavara U. Efficacy and safety of topical Trikatu preparation in, relieving mosquito bite reactions: a randomized controlled trial. Complement Ther Med 2014;22(1):34-9.
• Maghbooli M, Golipour F, Moghimi Esfandabadi A, Yousefi M. Comparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine. Phytother Res 2014;28(3):412-5.
• Mahady, G. B., Pendland, S. L., Stoia, A., Hamill, F. A., Fabricant, D., Dietz, B. M., and Chadwick, L. R. In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders. Phytother.Res 2005;19(11):988-991.
• Maharlouei N, Tabrizi R, Lankarani KB, et al. The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2018:1-14.
• Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Sci Nutr 2013;64(6):682-6.
• Mansour, M. S., Ni, Y. M., Roberts, A. L., Kelleman, M., Roychoudhury, A., and St-Onge, M. P. Ginger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: a pilot study. Metabolism 2012;61(10):1347-1352.
• Manusirivithaya S, Sripramote M, Tangjitgamol S, et al. Antiemetic effect of ginger in gynecologic oncology patients receiving cisplatin. Int J Gynecol Cancer 2004;14:1063-9.
• Marcus DM, Suarez-Almazor ME. Is there a role for ginger in the treatment of osteoarthritis? Arthritis Rheum 2001;44:2461-2.
• Martins LB, Rodrigues AMDS, Monteze NM, et al. Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) in the prophylactic treatment of migraine. Cephalalgia. 2020;40(1):88-95.
• Martins LB, Rodrigues AMDS, Rodrigues DF, Dos Santos LC, Teixeira AL, Ferreira AVM. Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) addition in migraine acute treatment. Cephalalgia. 2019;39(1):68-76.
• Marx W, McCarthy AL, Ried K, et al. The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial. Nutrients. 2017 Aug 12;9(8).
• Marx W, McKavanagh D, McCarthy AL, Bird R, Ried K, Chan A, Isenring L. The effect of ginger (Zingiber officinale) on platelet aggregation: A systematic literature review. PLoS One. 2015;10(10):e0141119.
• Matsumura MD, Zavorsky GS, Smoliga JM. The effects of pre-exercise ginger supplementation on muscle damage and delayed onset muscle soreness. Phytother Res. 2015;29(6):887-93.
• Matthews A, Dowswell T, Haas DM, et al. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2010;CD007575.
• Micklefield GH, Redeker Y, Meister V, et al. Effects of ginger on gastroduodenal motility. Int J Clin Pharmacol Ther 1999;37:341-6.
• Mohammad A, Falahi E, Mohd Yusof BN, et al. The effects of the ginger supplements on inflammatory parameters in type 2 diabetes patients: a systematic review and meta-analysis of randomised controlled trials. Clin Nutr ESPEN 2021;46:66-72.
• Mohammadbeigi R, Shahgeibi S, Soufizadeh N, et al. Comparing the effects of ginger and metoclopramide on the treatment of pregnancy nausea. Pak J Biol Sci. 2011;14:817-20.
• Morin AM, Betz O, Kranke P, et al. [Is ginger a relevant antiemetic for postoperative nausea and vomiting?]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2004;39:281-5.
• Morvaridzadeh M, Sadeghi E, Agah S, et al. Effect of ginger (Zingiber officinale) supplementation on oxidative stress parameters: A systematic review and meta-analysis. J Food Biochem. 2021;45(2):e13612.
• Mowrey DB, Clayson DE. Motion sickness, ginger, and psychophysics. Lancet. 1982;1:655-7.
• Mozafari S, Esmaeili S, Momenyan S, Zadeh Modarres S, Ozgoli G. Effect of Zingiber officinale Roscoe rhizome (ginger) capsule on postpartum pain: double-blind randomized clinical trial. J Res Med Sci 2021;26:105.
• Mozaffari-Khosravi H, Talaei B, Jalali BA, Najarzadeh A, Mozayan MR. The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complement Ther Med 2014;22(1):9-16.
• Nagabhushan M, Amonkar AJ, Bhide SV. Mutagenicity of gingerol and shogaol and antimutagenicity of zingerone in Salmonella/microsome assay. Cancer Lett 1987;36:221-33.
• Nanthakomon T, Pongrojpaw D. The efficacy of ginger in prevention of postoperative nausea and vomiting after major gynecologic surgery. J Med Assoc Thai. 2006;89:S130-6.
• Negi R, Sharma SK, Gaur R, Bahadur A, Jelly P. Efficacy of ginger in the treatment of primary dysmenorrhea: A systematic review and meta-analysis. Cureus 2021;13(3):e13743.
• Nguyen S, Rajfer J, Shaheen M. Safety and efficacy of daily Revactin in men with erectile dysfunction: a 3-month pilot study. Transl Androl Urol. 2018;7(2):266-73.
• Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, Sha W. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutr J 2013;12(1):154.
• Niempoog S, Siriarchavatana P, Kajsongkram T. The efficacy of Plygersic gel for use in the treatment of osteoarthritis of the knee. J Med Assoc Thai 2012;95 Suppl 10:S113-9.
• Nikkhah-Bodaghi M, Maleki I, Agah S, Hekmatdoost A. Zingiber officinale and oxidative stress in patients with ulcerative colitis: a randomized, placebo-controlled, clinical trial. Complement Ther Med 2019;43:1-6.
• Nocerino R, Cecere G, Micillo M, et al. Efficacy of ginger as antiemetic in children with acute gastroenteritis: a randomised controlled trial. Aliment Pharmacol Ther 2021;54(1):24-31.
• Nord D, Belew J. Effectiveness of the essential oils lavender and ginger in promoting children’s comfort in a perianesthesia setting. J Perianesth Nurs. 2009;24:307-12.
• Ojewole JA. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytother Res. 2006;20:764-72.
• Okonta JM, Uboh M, Obonga WO. Herb-Drug Interaction: A Case Study of Effect of Ginger on the Pharmacokinetic of Metronidazole in Rabbit. Indian Journal of Pharmaceutical Sciences (India) 2008;70(230):232.
• Okuhira H, Nakatani Y, Furukawa F, Kanazawa N. Anaphylaxis to ginger induced by herbal medicine. Allergol Int. 2020;69(1):159-160.
• Onogi, T., Minami, M., Kuraishi, Y., and Satoh, M. Capsaicin-like effect of (6)-shogaol on substance P-containing primary afferents of rats: a possible mechanism of its analgesic action. Neuropharmacology 1992;31(11):1165-1169.
• Onyenekwe, P. C. Assessment of oleoresin and gingerol contents in gamma irradiated ginger rhizomes. Nahrung 2000;44(2):130-132.
• Ozgoli G, Goli M, Moattar F. Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. J Altern Complement Med 2009;15:129-32.
• Pakniat H, Chegini V, Ranjkesh F, Hosseini MA. Comparison of the effect of vitamin E, vitamin D and ginger on the severity of primary dysmenorrhea: a single-blind clinical trial. Obstet Gynecol Sci. 2019;62(6):462-468.
• Pakniat H, Lalooha F, Movahed F, et al. The effect of ginger and metoclopramide in the prevention of nausea and vomiting during and after surgery in cesarean section under spinal anesthesia. Obstet Gynecol Sci. 2020;63(2):173-180.
• Paramdeep G. Efficacy and tolerability of ginger (Zingiber officinale) in patients of osteoarthritis of knee. Indian J Physiol Pharmacol 2013;57(2):177-83.
• Park, M., Bae, J., and Lee, D. S. Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria. Phytother.Res 2008;22(11):1446-1449.
• Pattanittum P, Kunyanone N, Brown J, et al. Dietary supplements for dysmenorrhoea. Cochrane Database Syst Rev. 2016;3:CD002124.
• Phan, P. V., Sohrabi, A., Polotsky, A., Hungerford, D. S., Lindmark, L., and Frondoza, C. G. Ginger extract components suppress induction of chemokine expression in human synoviocytes. J Altern.Complement Med 2005;11(1):149-154.
• Phillips S, Hutchinson S, Ruggier R. Zingiber officinale does not affect gastric emptying rate. A randomised, placebo-controlled, crossover trial. Anaesthesia 1993;48:393-5.
• Phillips S, Ruggier R, Hutchinson SE. Zingiber officinale (ginger)-an antiemetic for day case surgery. Anaesthesia 1993;48:715-7.
• Pillai AK, Sharma KK, Gupta YK, et al. Anti-emetic effect of ginger powder versus placebo as an add-on therapy in children and young adults receiving high emetogenic chemotherapy. Pediatr Blood Cancer. 2011;56:234-8.
• Pongrojpaw D, Chiamchanya C. The efficacy of ginger in prevention of post-operative nausea and vomiting after outpatient gynecological laparoscopy. J Med Assoc Thai. 2003;86:244-50.
• Pongrojpaw D, Somprasit C, Chanthasenanont A. A randomized comparison of ginger and dimenhydrinate in the treatment of nausea and vomiting in pregnancy. J Med Assoc Thai 2007;90:1703-9.
• Portnoi G, Chng LA, Karimi-Tabesh L, et al. Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy. Am J Obstet Gynecol 2003;189:1374-7.
• Pozzatti, P., Scheid, L. A., Spader, T. B., Atayde, M. L., Santurio, J. M., and Alves, S. H. In vitro activity of essential oils extracted from plants used as spices against fluconazole-resistant and fluconazole-susceptible Candida spp. Can J Microbiol. 2008;54(11):950-956.
• Prajapati, V., Tripathi, A. K., Aggarwal, K. K., and Khanuja, S. P. Insecticidal, repellent and oviposition-deterrent activity of selected essential oils against Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus. Bioresour.Technol. 2005;96(16):1749-1757.
• Pushpanathan, T., Jebanesan, A., and Govindarajan, M. The essential oil of Zingiber officinalis Linn (Zingiberaceae) as a mosquito larvicidal and repellent agent against the filarial vector Culex quinquefasciatus Say (Diptera: Culicidae). Parasitol.Res 2008;102(6):1289-1291.
• Qian, Q. H., Yue, W., Wang, Y. X., Yang, Z. H., Liu, Z. T., and Chen, W. H. Gingerol inhibits cisplatin-induced vomiting by down regulating 5-hydroxytryptamine, dopamine and substance P expression in minks. Arch Pharm.Res 2009;32(4):565-573.
• Rafie R, Hosseini SA, Hajiani E, Saki Malehi A, Mard SA. Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial. Clin Exp Gastroenterol. 2020;13:35-45.
• Rahnama P, Montazeri A, Huseini HF, Kianbakht S, Naseri M. Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial. BMC Complement Altern Med 2012;12:92.
• Rahuman, A. A., Gopalakrishnan, G., Venkatesan, P., Geetha, K., and Bagavan, A. Mosquito larvicidal activity of isolated compounds from the rhizome of Zingiber officinale. Phytother.Res 2008;22(8):1035-1039.
• Roberts AT, Martin CK, Liu Z, et al. The safety and efficacy of a dietary herbal supplement and gallic acid for weight loss. J Med Food. 2007;10:184-8.
• Ryan JL, Heckler CE, Roscoe JA, et al. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer. 2012;20:1479-89.
• Sahib AS. Treatment of irritable bowel syndrome using a selected herbal combination of Iraqi folk medicines. J Ethnopharmacol 2013;148(3):1008-12.
• Sambaiah, K. and Srinivasan, K. Effect of cumin, cinnamon, ginger, mustard and tamarind in induced hypercholesterolemic rats. Nahrung 1991;35(1):47-51.
• Sanaati F, Najafi S, Kashaninia Z, Sadeghi M. Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer. Asian Pac J Cancer Prev. 2016;17(8):4125-9.
• Schechter JO. Treatment of disequilibrium and nausea in the SRI discontinuation syndrome. J Clin Psychiatry 1998;59:431-2.
• Schmid R, Schick T, Steffen R, et al. Comparison of seven commonly used agents for prophylaxis of seasickness. J Travel Med 1994;1:102-106.
• Schwertner, H. A., Rios, D. C., and Pascoe, J. E. Variation in concentration and labeling of ginger root dietary supplements. Obstet.Gynecol. 2006;107(6):1337-1343.
• Sekiya, K., Ohtani, A., and Kusano, S. Enhancement of insulin sensitivity in adipocytes by ginger. Biofactors 2004;22(1-4):153-156.
• Shalansky S, Lynd L, Richardson K, et al. Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: a longitudinal analysis. Pharmacotherapy. 2007;27:1237-47.
• Shariatpanahi ZV, Taleban FA, Mokhtari M, et al. Ginger extract reduces delayed gastric emptying and nosocomial pneumonia in adult respiratory distress syndrome patients hospitalized in an intensive care unit. J Crit Care. 2010;25:647-50.
• Sharma, S. S. and Gupta, Y. K. Reversal of cisplatin-induced delay in gastric emptying in rats by ginger (Zingiber officinale). J Ethnopharmacol. 1998;62(1):49-55.
• Sheikhhossein F, Borazjani M, Jafari A, et al. Effects of ginger supplementation on biomarkers of oxidative stress: a systematic review and meta-analysis of randomized controlled trials. Clin Nutr ESPEN 2021;45:111-9.
• Shen, C. L., Hong, K. J., and Kim, S. W. Effects of ginger (Zingiber officinale Rosc.) on decreasing the production of inflammatory mediators in sow osteoarthrotic cartilage explants. J Med Food 2003;6(4):323-328.
• Shin, S. G., Kim, J. Y., Chung, H. Y., and Jeong, J. C. Zingerone as an antioxidant against peroxynitrite. J Agric.Food Chem. 9-21-2005;53(19):7617-7622.
• Shirvani MA, Motahari-Tabari N, Alipour A. The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial. Arch Gynecol Obstet. 2015;291(6):1277-81.
• Sihombing AT, Prabharani D, Lukman K, Sudjud RW. The effectiveness of ginger extract addition in calorified drinks during perioperative period to nausea severity, vomitus, post-operative anxiety, and metabolic disorder: A randomized control trial. Ann Med Surg (Lond). 2022 Nov 11;84:104865.
• Simon A, Darcsi A, Kéry Á, Riethmüller E. Blood-brain barrier permeability study of ginger constituents. J Pharm Biomed Anal. 2020;177:112820.
• Smith C, Crowther C, Wilson K et al. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol 2004;103:639-45.
• Sripramote, M. and Lekhyananda, N. A randomized comparison of ginger and vitamin B6 in the treatment of nausea and vomiting of pregnancy. J Med Assoc.Thai. 2003;86(9):846-853.
• Srivastava KC, Mustafa T. Ginger (Zingiber officinale) and rheumatic disorders. Med Hypotheses 1989;29:25-8.
• Srivastava KC. Effect of onion and ginger consumption on platelet thromboxane production in humans. Prostaglandins Leukot Essent Fatty Acids 1989;35:183-5.
• Srivastava, K. C. Isolation and effects of some ginger components on platelet aggregation and eicosanoid biosynthesis. Prostaglandins Leukot.Med. 1986;25(2-3):187-198.
• Stewart JJ, Wood MJ, Wood CD, Mims ME. Effects of ginger on motion sickness susceptibility and gastric function. Pharmacology 1991;42:111-20.
• Suekawa M, Ishige A, Yuasa K, et al. Pharmacological studies on ginger. I. Pharmacological actions of pungent constitutents, (6)-gingerol and (6)-shogaol. J Pharmacobiodyn 1984;7:836-48.
• Takahashi M, Li W, Koike K, et al. Clinical effectiveness of KSS formula, a traditional folk remedy for alcohol hangover symptoms. J Nat Med. 2010;64:487-91.
• Tao, Q. F., Xu, Y., Lam, R. Y., Schneider, B., Dou, H., Leung, P. S., Shi, S. Y., Zhou, C. X., Yang, L. X., Zhang, R. P., Xiao, Y. C., Wu, X., Stockigt, J., Zeng, S., Cheng, C. H., and Zhao, Y. Diarylheptanoids and a monoterpenoid from the rhizomes of Zingiber officinale: antioxidant and cytoprotective properties. J Nat.Prod. 2008;71(1):12-17.
• Tavlan A, Tuncer S, Erol A, et al. Prevention of postoperative nausea and vomiting after thyroidectomy: combined antiemetic treatment with dexamethasone and ginger versus dexamethasone alone. Clin Drug Investig. 2006;26:209-14.
• Terry R, Posadzki P, Watson LK, Ernst E. The use of ginger (Zingiber officinale) for the treatment of pain: a systematic review of clinical trials. Pain Med 2011;12:1808-18.
• Thamlikitkul L, Srimuninnimit V, Akewanlop C, et al. Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin-cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study. Support Care Cancer. 2017;25(2):459-464.
• Thomson M, Al-Qattan KK, Al-Sawan SM, et al. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins Leukot Essent Fatty Acids 2002;67:475-8.
• Thomson M, Corbin R, Leung L. Effects of ginger for nausea and vomiting in early pregnancy: a meta-analysis. J Am Board Fam Med 2014;27(1):115-22.
• Thongson, C., Davidson, P. M., Mahakarnchanakul, W., and Vibulsresth, P. Antimicrobial effect of Thai spices against Listeria monocytogenes and Salmonella typhimurium DT104. J Food Prot. 2005;68(10):2054-2058.
• Tosun B, Unal N, Yigit D, Can N, Aslan O, Tunay S. Effects of Self-Knee Massage With Ginger Oil in Patients With Osteoarthritis: An Experimental Study. Res Theory Nurs Pract. 2017;31(4):379-392.
• Tóth B, Lantos T, Hegyi P, et al. Ginger (Zingiber officinale): An alternative for the prevention of postoperative nausea and vomiting. A meta-analysis. Phytomedicine. 2018 Nov 15;50:8-18. Epub 2018 Sep 5.
• Uthaipaisanwong A, Oranratanaphan S, Musigavong N. Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study. Support Care Cancer. 2019.
• Vahdat Shariatpanahi Z, Mokhtari M, Taleban FA, Alavi F, Salehi Surmaghi MH, Mehrabi Y, Shahbazi S. Effect of enteral feeding with ginger extract in acute respiratory distress syndrome. J Crit Care 2013;28(2):217.e1-6.
• van Tilburg MA, Palsson OS, Ringel Y, Whitehead WE. Is ginger effective for the treatment of irritable bowel syndrome? A double blind randomized controlled pilot trial. Complement Ther Med 2014;22(1):17-20.
• Verma, S. K., Singh, J., Khamesra, R., and Bordia, A. Effect of ginger on platelet aggregation in man. Indian J Med.Res 1993;98:240-242.
• Viljoen E, Visser J, Koen N, Musekiwa A. A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting. Nutr J 2014;13:20.
• Visalyaputra S, Petchpaisit N, Somcharoen K, Choavaratana R. The efficacy of ginger root in the prevention of postoperative nausea and vomiting after outpatient gynaecological laparoscopy. Anaesthesia 1998;53:506-10.
• Vutyavanich T, Kraisarin T, Ruangsri R. Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial. Obstet Gynecol 2001;97:577-82.
• Weidner MS, Sigwart K. Investigation of the teratogenic potential of a zingiber officinale extract in the rat. Reprod Toxicol 2001;15:75-80.
• Wigler I, Grotto I, Caspi D, Yaron M. The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarthritis Cartilage 2003;11:783-9.
• Wilkinson JM. Effect of ginger tea on the fetal development of Sprague-Dawley rats. Reprod Toxicol 2000;14:507-12.
• Wood CD, Manno JE, Wood MJ, et al. Comparison of efficacy of ginger with various antimotion sickness drugs. Clin Res Pr Drug Regul Aff 1988;6:129-36.
• Wu, C. X., Wei, X. B., Ding, H., Sun, X., and Cheng, X. M. [Protective effect of effective parts of Zingiber Offecinal on vascular endothelium of the experimental hyperlipidemic rats]. Zhong.Yao Cai. 2006;29(8):810-813.
• Wu, K. L., Rayner, C. K., Chuah, S. K., Changchien, C. S., Lu, S. N., Chiu, Y. C., Chiu, K. W., and Lee, C. M. Effects of ginger on gastric emptying and motility in healthy humans. Eur.J Gastroenterol.Hepatol. 2008;20(5):436-440.
• Yamahara J, Rong HQ, Iwamoto M, and et al. Active components of ginger exhibiting anti-serotonergic action. Phytotherapy Res 1989;3(2):70-71.
• Yamahara, J., Huang, Q. R., Li, Y. H., Xu, L., and Fujimura, H. Gastrointestinal motility enhancing effect of ginger and its active constituents. Chem.Pharm.Bull.(Tokyo) 1990;38(2):430-431.
• Yamahara, J., Mochizuki, M., Rong, H. Q., Matsuda, H., and Fujimura, H. The anti-ulcer effect in rats of ginger constituents. J Ethnopharmacol. 1988;23(2-3):299-304.
• Yamprasert R, Chanvimalueng W, Mukkasombut N, Itharat A. Ginger extract versus Loratadine in the treatment of allergic rhinitis: a randomized controlled trial. BMC Complement Med Ther. 2020;20(1):116.
• Yip YB, Tam AC. An experimental study on the effectiveness of massage with aromatic ginger and orange essential oil for moderate-to-severe knee pain among the elderly in Hong Kong. Complement Ther Med. 2008;16:131-8.
• Young HY, Liao JC, Chang YS, et al. Synergistic effect of ginger and nifedipine on human platelet aggregation: a study in hypertensive patients and normal volunteers. Am J Chin Med. 2006;34:545-51.
• Yousefi O, Ghazi-Mirsaiid S, Azami P, et al. Effect of a Boswellia and Ginger mixture on the memory dysfunction of the mild traumatic brain injury patients: a randomized, double-blind controlled trial. Bull Emerg Trauma. 2022;10(4):157-64. doi: 10.30476/BEAT.2022.97106.1400.
• Yu, Y., Zick, S., Li, X., Zou, P., Wright, B., and Sun, D. Examination of the pharmacokinetics of active ingredients of ginger in humans. AAPS.J. 2011;13(3):417-426.
• Zahmatkash M, Vafaeenasab MR. Comparing analgesic effects of a topical herbal mixed medicine with salicylate in patients with knee osteoarthritis. Pak J Biol Sci. 2011;14:715-9.
• Zegota Z, Gozdzik J, Glogowska-Szelag J. Prospective, multicenter evaluation of a polyherbal supplement alongside standard-of-care treatment for mild knee osteoarthritis. Adv Orthop. 2021;2021:5589597.
• Zhang S, DiMango E, Zhu Y, Saroya TK, Emala CW, Sang S. Pharmacokinetics of Gingerols, Shogaols, and Their Metabolites in Asthma Patients. J Agric Food Chem 2022;70(31):9674-9683.
• Zhang, G. F., Yang, Z. B., Wang, Y., Yang, W. R., Jiang, S. Z., and Gai, G. S. Effects of ginger root (Zingiber officinale) processed to different particle sizes on growth performance, antioxidant status, and serum metabolites of broiler chickens. Poult.Sci 2009;88(10):2159-2166.
• Zhu J, Chen H, Song Z, Wang X, Sun Z. Effects of Ginger (Zingiber officinale Roscoe) on Type 2 Diabetes Mellitus and Components of the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complement Alt Med 2018.
• Zick, S. M., Djuric, Z., Ruffin, M. T., Litzinger, A. J., Normolle, D. P., Alrawi, S., Feng, M. R., and Brenner, D. E. Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects. Cancer Epidemiol.Biomarkers Prev. 2008;17(8):1930-1936.
• Zick, S. M., Ruffin, M. T., Lee, J., Normolle, D. P., Siden, R., Alrawi, S., and Brenner, D. E. Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting. Support.Care Cancer 2009;17(5):563-572.
• Zick, S. M., Turgeon, D. K., Vareed, S. K., Ruffin, M. T., Litzinger, A. J., Wright, B. D., Alrawi, S., Normolle, D. P., Djuric, Z., and Brenner, D. E. Phase II study of the effects of ginger root extract on eicosanoids in colon mucosa in people at normal risk for colorectal cancer. Cancer Prev.Res.(Phila) 2011;4(11):1929-1937.

Lemongrass

• Abe, S., Maruyama, N., Hayama, K., Inouye, S., Oshima, H., and Yamaguchi, H. Suppression of neutrophil recruitment in mice by geranium essential oil. Mediators.Inflamm. 2004;13(1):21-24.
• Abe, S., Sato, Y., Inoue, S., Ishibashi, H., Maruyama, N., Takizawa, T., Oshima, H., and Yamaguchi, H. [Anti-Candida albicans activity of essential oils including Lemongrass (Cymbopogon citratus) oil and its component, citral]. Nippon Ishinkin.Gakkai Zasshi 2003;44(4):285-291.
• Adeneye, A. A. and Agbaje, E. O. Hypoglycemic and hypolipidemic effects of fresh leaf aqueous extract of Cymbopogon citratus Stapf. in rats. J Ethnopharmacol. 7-25-2007;112(3):440-444.
• Adukwu EC, Bowles M, Edwards-Jones V, Bone H. Antimicrobial activity, cytotoxicity and chemical analysis of lemongrass essential oil (Cymbopogon flexuosus) and pure citral. Appl Microbiol Biotechnol 2016;100(22):9619-27.
• Akula S, Nagarathna J, Srinath K. Anti-Plaque and Anti-Gingivitis Efficacy of 0.25% Lemongrass Oil and 0.2% Chlorhexidine Mouthwash in Children. Front Dent 2021;18:32.
• Avoseh O, Oyedeji O, Rungqu P, Nkeh-Chungag B, Oyedeji A. Cymbopogon species; ethnopharmacology, phytochemistry and the pharmacological importance. Molecules 2015;20(5):7438-53.
• Blanco, M. M., Costa, C. A., Freire, A. O., Santos, J. G., Jr., and Costa, M. Neurobehavioral effect of essential oil of Cymbopogon citratus in mice. Phytomedicine 2009;16(2-3):265-270.
• Bleasel, N., Tate, B., and Rademaker, M. Allergic contact dermatitis following exposure to essential oils. Australas.J Dermatol 2002;43(3):211-213.
• Boukhatem MN, Ferhat MA, Kameli A, Saidi F, Kebir H93T. Lemon grass (Cymbopogon citratus) essential oil as a potent anti-inflammatory and antifungal drugs. Libyan J Med 2014;9:25431.
• Buckle J. Use of aromatherapy as a complementary treatment for chronic pain. Altern Ther Health Med 1999;5:42-51.
• Chaisripipat W, Lourith N, Kanlayavattanakul M. Anti-dandruff hair tonic containing lemongrass (Cymbopogon flexuosus) oil. Forsch Komplementmed 2015;22(4):226-9.
• Cheel, J., Theoduloz, C., Rodriguez, J., and Schmeda-Hirschmann, G. Free radical scavengers and antioxidants from Lemongrass (Cymbopogon citratus (DC.) Stapf.). J Agric.Food Chem 4-6-2005;53(7):2511-2517.
• Chukwuocha UM, Fernández-Rivera O, Legorreta-Herrera M. Exploring the antimalarial potential of whole Cymbopogon citratus plant therapy. J Ethnopharmacol 2016;193:517-23.
• Costa CA, Kohn DO, de Lima VM, Gargano AC, Flório JC, Costa M. The GABAergic system contributes to the anxiolytic-like effect of essential oil from Cymbopogon citratus (lemongrass). J Ethnopharmacol 2011;137(1):828-36.
• Dorman HJ, Deans SG. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 2000;88:308-16.
• Dr. Duke’s Phytochemical and Ethnobotanical Databases. Available at: http://www.ars-grin.gov/duke/.
• Dudai N, Weinstein Y, Krup M, et al. Citral is a new inducer of caspase-3 in tumor cell lines. Planta Med 2005;71:484-8.
• Electronic Code of Federal Regulations. Title 21. Part 182 — Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
• Elson, C. E., Underbakke, G. L., Hanson, P., Shrago, E., Wainberg, R. H., and Qureshi, A. A. Impact of lemongrass oil, an essential oil, on serum cholesterol. Lipids 1989;24(8):677-679.
• Figueirinha, A., Cruz, M. T., Francisco, V., Lopes, M. C., and Batista, M. T. Anti-inflammatory activity of Cymbopogon citratus leaf infusion in lipopolysaccharide-stimulated dendritic cells: contribution of the polyphenols. J Med Food 2010;13(3):681-690.
• Frosch, P. J., Johansen, J. D., Menne, T., Pirker, C., Rastogi, S. C., Andersen, K. E., Bruze, M., Goossens, A., Lepoittevin, J. P., and White, I. R. Further important sensitizers in patients sensitive to fragrances. Contact Dermatitis 2002;47(5):279-287.
• Halabi MF, Sheikh BY. Anti-proliferative effect and phytochemical analysis of Cymbopogon citratus extract. Biomed Res Int 2014;2014:906239.
• Kimutai A, Ngeiywa M, Mulaa M, et al. Repellent effects of the essential oils of Cymbopogon citratus and Tagetes minuta on the sandfly, Phlebotomus duboscqi. BMC Res Notes 2017;10(1):98.
• Lalko, J. and Api, A. M. Investigation of the dermal sensitization potential of various essential oils in the local lymph node assay. Food Chem Toxicol 2006;44(5):739-746.
• Lee, H. J., Jeong, H. S., Kim, D. J., Noh, Y. H., Yuk, D. Y., and Hong, J. T. Inhibitory effect of citral on NO production by suppression of iNOS expression and NF-kappa B activation in RAW264.7 cells. Arch Pharm.Res 2008;31(3):342-349.
• Leite JR, Seabra Mde L, Maluf E, et al. Pharmacology of lemongrass (Cymbopogon citratus Stapf). III. Assessment of eventual toxic, hypnotic and anxiolytic effects on humans. J Ethnopharmacol 1986;17:75-83.
• Li CC, Yu HF, Chang CH, Liu YT, Yao HT. Effects of lemongrass oil and citral on hepatic drug-metabolizing enzymes, oxidative stress, and acetaminophen toxicity in rats. J Food Drug Anal 2018;26(1):432-8.
• Lorenzetti, B. B., Souza, G. E., Sarti, S. J., Santos, Filho D., and Ferreira, S. H. Myrcene mimics the peripheral analgesic activity of lemongrass tea. J Ethnopharmacol 1991;34(1):43-48.
• Manikandan S, Bhambal AM, Ratchambiga KS, Nithiela M, Swatheka JK, Sridarshini B. Comparative Evaluation of the Effect of 0.2% Chlorhexidine, 2% LemonGrass Oil, and 2% Tea Tree Oil Mouth rinse on Salivary pH: An In vivo Study. J Pharm Bioallied Sci 2021;13(Suppl 1):S757-S760.
• Meenapriya M, Priya J. Effect of lemongrass oil on rheumatoid arthritis. J Pharm Sci Res 2017;9(2):237-9.
• Nakamura, Y., Miyamoto, M., Murakami, A., Ohigashi, H., Osawa, T., and Uchida, K. A phase II detoxification enzyme inducer from lemongrass: identification of citral and involvement of electrophilic reaction in the enzyme induction. Biochem Biophys Res Commun. 3-14-2003;302(3):593-600.
• Ohno, T., Kita, M., Yamaoka, Y., Imamura, S., Yamamoto, T., Mitsufuji, S., Kodama, T., Kashima, K., and Imanishi, J. Antimicrobial activity of essential oils against Helicobacter pylori. Helicobacter. 2003;8(3):207-215.
• Oliveira, V. C., Moura, D. M., Lopes, J. A., de Andrade, P. P., da Silva, N. H., and Figueiredo, R. C. Effects of essential oils from Cymbopogon citratus (DC) Stapf., Lippia sidoides Cham., and Ocimum gratissimum L. on growth and ultrastructure of Leishmania chagasi promastigotes. Parasitol.Res 2009;104(5):1053-1059.
• Pereira, R. P., Fachinetto, R., de Souza, Prestes A., Puntel, R. L., Santos da Silva, G. N., Heinzmann, B. M., Boschetti, T. K., Athayde, M. L., Burger, M. E., Morel, A. F., Morsch, V. M., and Rocha, J. B. Antioxidant effects of different extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citratus. Neurochem.Res. 2009;34(5):973-983.
• Pushpanathan, T., Jebanesan, A., and Govindarajan, M. Larvicidal, ovicidal and repellent activities of Cymbopogan citratus Stapf (Graminae) essential oil against the filarial mosquito Culex quinquefasciatus (Say) (Diptera : Culicidae). Trop.Biomed. 2006;23(2):208-212.
• Rao, V. S., Menezes, A. M., and Viana, G. S. Effect of myrcene on nociception in mice. J Pharm Pharmacol 1990;42(12):877-878.
• Santin, M. R., dos Santos, A. O., Nakamura, C. V., Dias Filho, B. P., Ferreira, I. C., and Ueda-Nakamura, T. In vitro activity of the essential oil of Cymbopogon citratus and its major component (citral) on Leishmania amazonensis. Parasitol.Res 2009;105(6):1489-1496.
• Santoro, G. F., Cardoso, M. G., Guimaraes, L. G., Freire, J. M., and Soares, M. J. Anti-proliferative effect of the essential oil of Cymbopogon citratus (DC) Stapf (lemongrass) on intracellular amastigotes, bloodstream trypomastigotes and culture epimastigotes of Trypanosoma cruzi (Protozoa: Kinetoplastida). Parasitology 2007;134(Pt 11):1649-1656.
• Sforcin, J. M., Amaral, J. T., Fernandes, A., Jr., Sousa, J. P., and Bastos, J. K. Lemongrass effects on IL-1beta and IL-6 production by macrophages. Nat.Prod.Res 2009;23(12):1151-1159.
• Shah G, Shri R, Panchal V, Sharma N, Singh B, Mann AS. Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemon grass). J Adv Pharm Technol Res 2011;2(1):3-8.
• Silva, M. R., Ximenes, R. M., da Costa, J. G., Leal, L. K., de Lopes, A. A., and Viana, G. S. Comparative anticonvulsant activities of the essential oils (EOs) from Cymbopogon winterianus Jowitt and Cymbopogon citratus (DC) Stapf. in mice. Naunyn Schmiedebergs Arch Pharmacol 2010;381(5):415-426.
• Soonwera M, Phasomkusolsil S. Effect of Cymbopogon citratus (lemongrass) and Syzygium aromaticum (clove) oils on the morphology and mortality of Aedes aegypti and Anopheles dirus larvae. Parasitol Res 2016;115(4):1691-703.
• Tapia, A., Cheel, J., Theoduloz, C., Rodriguez, J., Schmeda-Hirschmann, G., Gerth, A., Wilken, D., Jordan, M., Jimenez-Gonzalez, E., Gomez-Kosky, R., and Mendoza, E. Q. Free radical scavengers from Cymbopogon citratus (DC.) stapf plants cultivated in bioreactors by the temporary immersion (TIS) principle. Z.Naturforsch.C 2007;62(5-6):447-457.
• Tchoumbougnang, F., Zollo, P. H., Dagne, E., and Mekonnen, Y. In vivo antimalarial activity of essential oils from Cymbopogon citratus and Ocimum gratissimum on mice infected with Plasmodium berghei. Planta Med 2005;71(1):20-23.
• Trongtokit, Y., Rongsriyam, Y., Komalamisra, N., and Apiwathnasorn, C. Comparative repellency of 38 essential oils against mosquito bites. Phytother Res 2005;19(4):303-309.
• Viana, G. S., Vale, T. G., Pinho, R. S., and Matos, F. J. Antinociceptive effect of the essential oil from Cymbopogon citratus in mice. J Ethnopharmacol 2000;70(3):323-327.
• Wohrl, S., Hemmer, W., Focke, M., Gotz, M., and Jarisch, R. The significance of fragrance mix, balsam of Peru, colophony and propolis as screening tools in the detection of fragrance allergy. Br.J Dermatol. 2001;145(2):268-273.
• Wright, S. C., Maree, J. E., and Sibanyoni, M. Treatment of oral thrush in HIV/AIDS patients with lemon juice and lemon grass (Cymbopogon citratus) and gentian violet. Phytomedicine 2009;16(2-3):118-124.

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